Esculetin protects human corneal epithelial cells from oxidative stress through Nrf-2 signaling pathway.
Autor: | Zhang Y; The School of Pharmacy, He University, Shenyang, 110163, China., An Y; The School of Pharmacy, He University, Shenyang, 110163, China., He X; The School of Pharmacy, He University, Shenyang, 110163, China; Shenyang Industrial Technology Institute of Ophthalmology, Shenyang, 110163, China., Zhang D; The School of Pharmacy, He University, Shenyang, 110163, China. Electronic address: zhangdonglei@huh.edu.cn., He W; The School of Pharmacy, He University, Shenyang, 110163, China; Shenyang Industrial Technology Institute of Ophthalmology, Shenyang, 110163, China. Electronic address: hewei@huh.edu.cn. |
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Jazyk: | angličtina |
Zdroj: | Experimental eye research [Exp Eye Res] 2021 Jan; Vol. 202, pp. 108360. Date of Electronic Publication: 2020 Nov 19. |
DOI: | 10.1016/j.exer.2020.108360 |
Abstrakt: | Dry eye formation often originates from oxidative damage to the ocular surface, which can be caused by external environment or internal pathologic factors. Esculetin (6, 7-dihydroxycoumarin) is a natural product found in many plants, and has been reported to have multiple pharmacological activities. The objective of our present study is to investigate if esculetin could protect the corneal epithelial cells from oxidative damages and its underlying antioxidant molecular mechanisms. Our experimental results demonstrated that pretreatment with esculetin markedly increased the cell viability while decreased the apoptosis in H (Copyright © 2020 Elsevier Ltd. All rights reserved.) |
Databáze: | MEDLINE |
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