| Autor: |
Tan ST; University of Malaya Medical Center, Faculty of Medicine, Department of Surgery, 50603 Kuala Lumpur, Malaysia. ncltan10@gmail.com., Yoong BK; University of Malaya Medical Center, Faculty of Medicine, Department of Surgery, 50603 Kuala Lumpur, Malaysia. |
| Jazyk: |
angličtina |
| Zdroj: |
The Medical journal of Malaysia [Med J Malaysia] 2020 Nov; Vol. 75 (6), pp. 734-735. |
| Abstrakt: |
Tacrolimus, which bonds to an immunophilin, FK506 binding protein (FKBP) has emerged as one of the most widely used immunosuppressant post solid organ transplantation. It offers excellent patient survival rates post-transplantation and a lesser number of acute rejections as compared to cyclosporine. Tacrolimus has a narrow therapeutic window with overexposure leading to acute and chronic forms of nephrotoxicity. Remarkably few data have been published on the overexposure to tacrolimus following mild diarrhoea in post-transplant patients who received treatment with tacrolimus. We observed a post-liver transplant patient with increased trough level of tacrolimus during severe diarrhoea with no complications following a timely adjustment on the dose of tacrolimus. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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