Needle-compatible miniaturized optoelectronic sensor for pancreatic cancer detection.

Autor:	Lee SY; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA., Pakela JM; Applied Physics Program, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA., Na K; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA., Shi J; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA., McKenna BJ; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA., Simeone DM; Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA., Yoon E; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA., Scheiman JM; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Mycek MA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. mycek@umich.edu.; Applied Physics Program, University of Michigan, Ann Arbor, MI 48109, USA.; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2020 Nov 20; Vol. 6 (47). Date of Electronic Publication: 2020 Nov 20 (Print Publication: 2020).
DOI:	10.1126/sciadv.abc1746
Abstrakt:	Pancreatic cancer is one of the deadliest cancers, with a 5-year survival rate of <10%. The current approach to confirming a tissue diagnosis, endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), requires a time-consuming, qualitative cytology analysis and may be limited because of sampling error. We designed and engineered a miniaturized optoelectronic sensor to assist in situ, real-time, and objective evaluation of human pancreatic tissues during EUS-FNA. A proof-of-concept prototype sensor, compatible with a 19-gauge hollow-needle commercially available for EUS-FNA, was constructed using microsized optoelectronic chips and microfabrication techniques to perform multisite tissue optical sensing. In our bench-top verification and pilot validation during surgery on freshly excised human pancreatic tissues (four patients), the fabricated sensors showed a comparable performance to our previous fiber-based system. The flexibility in source-detector configuration using microsized chips potentially allows for various light-based sensing techniques inside a confined channel such as a hollow needle or endoscopy. (Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).)
Databáze:	MEDLINE
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