Air pollution from traffic during pregnancy impairs newborn's cord blood immune cells: The NELA cohort.

Autor: García-Serna AM; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; University of Murcia, Murcia, Spain., Hernández-Caselles T; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; University of Murcia, Murcia, Spain; Network of Asthma and Adverse and Allergic Reactions (ARADyAL), Spain., Jiménez-Guerrero P; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; University of Murcia, Murcia, Spain., Martín-Orozco E; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; University of Murcia, Murcia, Spain; Network of Asthma and Adverse and Allergic Reactions (ARADyAL), Spain., Pérez-Fernández V; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; University of Murcia, Murcia, Spain; Network of Asthma and Adverse and Allergic Reactions (ARADyAL), Spain., Cantero-Cano E; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain., Muñoz-García M; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; University of Murcia, Murcia, Spain., Ballesteros-Meseguer C; University of Murcia, Murcia, Spain; Virgen de la Arrixaca University Clinical Hospital, Murcia, Spain., Pérez de Los Cobos I; Virgen de la Arrixaca University Clinical Hospital, Murcia, Spain., García-Marcos L; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; University of Murcia, Murcia, Spain; Network of Asthma and Adverse and Allergic Reactions (ARADyAL), Spain; Virgen de la Arrixaca University Clinical Hospital, Murcia, Spain., Morales E; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; University of Murcia, Murcia, Spain. Electronic address: embarto@hotmail.com.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2021 Jul; Vol. 198, pp. 110468. Date of Electronic Publication: 2020 Nov 17.
DOI: 10.1016/j.envres.2020.110468
Abstrakt: Background: Hazards of traffic-related air pollution (TRAP) on the developing immune system are poorly understood. We sought to investigate the effects of prenatal exposure to TRAP on cord blood immune cell distributions; and to identify gestational windows of susceptibility.
Methods: In-depth immunophenotyping of cord blood leukocyte and lymphocyte subsets was performed by flow cytometry in 190 newborns embedded in the Nutrition in Early Life and Asthma (NELA) birth cohort (2015-2018). Long-term (whole pregnancy and trimesters) and short-term (15-days before delivery) residential exposures to traffic-related nitrogen dioxide (NO 2 ), particulate matter (PM 2.5 and PM 10 ), and ozone (O 3 ) were estimated using dispersion/chemical transport modelling. Associations between TRAP concentrations and cord blood immune cell counts were assessed using multivariate Poisson regression models.
Results: Mean number of natural killer (NK) cells decreased 15% in relation to higher NO 2 concentrations (≥36.4 μg/m3) during whole pregnancy (incidence relative risk (IRR), 0.85; 95% CI, 0.72, 0.99), with stronger associations in the first trimester. Higher PM 2.5 concentrations (≥13.3 μg/m 3 ) during whole pregnancy associated with a reduced mean number of cytotoxic T cells (IRR, 0.88; 95% CI, 0.78, 0.99). Newborns exposed to higher PM 10 (≥23.6 μg/m 3 ) and PM 2.5 concentrations during the first and third trimester showed greater mean number of helper T type 1 (Th1) cells (P < 0.05). Decreased number of regulatory T (Treg) cells was associated with greater short-term NO 2 (IRR, 0.90; 95% CI, 0.80, 1.01) and PM 10 (IRR, 0.88; 95% CI, 0.77, 0.99) concentrations.
Conclusions: Prenatal exposure to TRAP, particularly in early and late gestation, impairs fetal immune system development through disturbances in cord blood leukocyte and lymphocyte distributions.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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