Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy.

Autor: Grilo EC; Postgraduate Health Sciences Program, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Cunha TA; Postgraduate Health Sciences Program, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Costa ÁDS; Postgraduate Nutrition Program, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Araújo BGM; Nutrition Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Lopes MMGD; Nutrition Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Maciel BLL; Nutrition Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Alves CX; Neurology outpatient facility, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Vermeulen-Serpa KM; Postgraduate Health Sciences Program, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Dourado-Júnior MET; Department of Internal Medicine, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Leite-Lais L; Nutrition Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Brandão-Neto J; Department of Internal Medicine, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Vale SHL; Nutrition Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Nov 20; Vol. 15 (11), pp. e0241722. Date of Electronic Publication: 2020 Nov 20 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0241722
Abstrakt: The evaluation of fat-free mass (FFM) in patients with Duchenne muscular dystrophy (DMD) is useful to investigate disease progression and therapeutic efficacy. This study aimed to validate the Bioelectrical impedance (BIA) method compared with the dual-energy X-ray absorptiometry (DXA) for estimating the %FFM in boys with DMD. This is a cross-sectional study performed with children and adolescents diagnosed with DMD. Resistance and reactance were measured with a BIA analyzer, from which eight predictive equations estimated the %FFM. The %FFM was also determined by DXA and its used as a reference method. Pearson correlation test, coefficient of determination, the root-mean-square error, the interclass correlation coefficient, and linear regression analysis were performed between %FFM values obtained by BIA and DXA. The agreement between these values was verified with the Bland-Altman plot analysis. Forty-six boys aged from 5 to 20 years were enrolled in the study. All the equations showed a correlation between the %FFM estimated by BIA and determined by DXA (p < 0.05). The Bland-Altman method indicated that two equations have a significant bias (p < 0.05) and six equations showed no significant bias of %FFM (p > 0.05). However, one of them has high variation and wide limits of agreement. Five of eight %FFM predictive equations tested in DMD were accurate when compared with the DXA. It can be concluded that BIA is a validity method to evaluate patients with DMD.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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