Incidence of Nonalcoholic Fatty Liver Disease in Children: 2009-2018.

Autor:	Sahota AK; Southern California Permanente Medical Group, Pasadena, California.; Contributed equally as co-first authors., Shapiro WL; Southern California Permanente Medical Group, Pasadena, California.; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California; and.; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Rady Children's Hospital, San Diego, California.; Contributed equally as co-first authors., Newton KP; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California; and.; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Rady Children's Hospital, San Diego, California., Kim ST; Southern California Permanente Medical Group, Pasadena, California., Chung J; Southern California Permanente Medical Group, Pasadena, California., Schwimmer JB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California; and jschwimmer@ucsd.edu.; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Rady Children's Hospital, San Diego, California.
Jazyk:	angličtina
Zdroj:	Pediatrics [Pediatrics] 2020 Dec; Vol. 146 (6).
DOI:	10.1542/peds.2020-0771
Abstrakt:	Background and Objectives: In 2007, the American Academy of Pediatrics recommended that children with obesity should be screened for nonalcoholic fatty liver disease (NAFLD). Population epidemiology reveals that NAFLD is common in children; however, little is known about rates of clinical diagnosis. In this study, we aim to determine screening practices, annual incidence, and clinical characteristics of NAFLD in children within an integrated community health system. Methods: Using electronic health records, we identified patients newly diagnosed (aged 5-18) with NAFLD on the basis of diagnostic codes from the 9th and 10th revisions of the International Classification of Diseases . We calculated screening rates and annual incidence rates of NAFLD from January 1, 2009, to December 31, 2018. Results: In this study, we evaluated 7 884 844 patient-years. Screening was performed in 54.0% of children with obesity and 24.0% of children with overweight. The results revealed 36 658 children aged 9 to 18 with overweight or obesity and alanine aminotransferase >30 U/L. Of these children, 12.3% received further workup for NAFLD. The incidence of an NAFLD diagnosis significantly increased over time, with 36.0 per 100 000 in 2009 and 58.2 per 100 000 in 2018 ( P < .0001). Conclusions: Our study of a large integrated health care system in southern California revealed that the incidence of NAFLD in children is increasing, although many children may remain undiagnosed. Competing Interests: POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose. (Copyright © 2020 by the American Academy of Pediatrics.)
Databáze:	MEDLINE
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