Lack of Evidence for Stereotypical Direction Columns in the Mouse Superior Colliculus.

Autor:	Chen H; Department of Biology and Department of Psychology, University of Virginia, Charlottesville, Virginia 22904., Savier EL; Department of Biology and Department of Psychology, University of Virginia, Charlottesville, Virginia 22904., DePiero VJ; Department of Biology and Department of Psychology, University of Virginia, Charlottesville, Virginia 22904., Cang J; Department of Biology and Department of Psychology, University of Virginia, Charlottesville, Virginia 22904 cang@virginia.edu.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Jan 20; Vol. 41 (3), pp. 461-473. Date of Electronic Publication: 2020 Nov 19.
DOI:	10.1523/JNEUROSCI.1155-20.2020
Abstrakt:	Neurons in the visual system can be spatially organized according to their response properties such as receptive field location and feature selectivity. For example, the visual cortex of many mammalian species contains orientation and direction columns where neurons with similar preferences are clustered. Here, we examine whether such a columnar structure exists in the mouse superior colliculus (SC), a prominent visual center for motion processing. By performing large-scale physiological recording and two-photon calcium imaging in adult male and female mice, we show that direction-selective neurons in the mouse SC are not organized into stereotypical columns as a function of their preferred directions, although clusters of similarly tuned neurons are seen in a minority of mice. Nearby neurons can prefer similar or opposite directions in a largely position-independent manner. This finding holds true regardless of animal state (anesthetized vs awake, running vs stationary), SC depth (most superficial lamina vs deeper in the SC), research technique (calcium imaging vs electrophysiology), and stimulus type (drifting gratings vs moving dots, full field vs small patch). Together, these results challenge recent reports of region-specific organizations in the mouse SC and reveal how motion direction is represented in this important visual center. (Copyright © 2021 the authors.)
Databáze:	MEDLINE
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