Essential Tremor - A Cerebellar Driven Disorder?

Autor: Ibrahim MF; Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand. Electronic address: ruth.empson@otago.ac.nz., Beevis JC; Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand., Empson RM; Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.
Jazyk: angličtina
Zdroj: Neuroscience [Neuroscience] 2021 May 10; Vol. 462, pp. 262-273. Date of Electronic Publication: 2020 Nov 17.
DOI: 10.1016/j.neuroscience.2020.11.002
Abstrakt: Abnormal tremors are the most common of all movement disorders. In this review we focus on the role of the cerebellum in Essential Tremor, a highly debilitating but poorly treated movement disorder. We propose a variety of mechanisms driving abnormal burst firing of deep cerebellar nuclei neurons as a key initiator of tremorgenesis in Essential Tremor. Targetting these mechanisms may generate more effective treatments for Essential Tremor.
(Copyright © 2020. Published by Elsevier Ltd.)
Databáze: MEDLINE
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