Perinatal factors affecting platelet parameters in late preterm and term neonates.

Autor: Go H; Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan., Ohto H; Department of Advanced Cancer Immunotherapy, Fukushima Medical University School of Medicine, Fukushima, Japan., Nollet KE; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan., Kashiwabara N; Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan., Chishiki M; Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan., Hoshino M; Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan., Ogasawara K; Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan., Kawasaki Y; Department of Pediatrics, Sapporo Medical University School of Medicine, Hokkaido, Japan., Momoi N; Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan., Hosoya M; Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Nov 19; Vol. 15 (11), pp. e0242539. Date of Electronic Publication: 2020 Nov 19 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0242539
Abstrakt: Platelets parameters including platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) are associated with various physiological and pathological functions in various disease. However, few studies have addressed whether perinatal factors may be associated with platelet parameters at birth in a large cohort of late preterm and term neonates. The aim of this study to investigate perinatal factors affecting platelet parameters in late preterm and term neonates. We retrospectively investigated platelet parameters including PLT, PCT, MPV, and PDW on the first day of life in 142 late preterm and 258 term neonates admitted to our NICU from 2006 through 2020. PLT, MPV, PCT, PDW on Day 0 did not significantly differ between the two groups. In term neonates, multivariate analysis revealed that PCT correlated with being small for gestational age (SGA) (β = -0.168, P = 0.006), pregnancy induced hypertension (PIH) (β = -0.135, P = 0.026) and male sex (β = -0.185, P = 0.002). PLT was associated with SGA (β = -0.186, P = 0.002), PIH (β = -0.137, P = 0.024) and male sex (β = -0.166, P = 0.006). In late preterm neonates, multivariate analysis revealed that PLT were associated with PIH, whereas no factors associated with PDW and MPV were found. In all patients studied, chorioamnionitis (CAM) was significantly associated with MPV (CAM = 10.3 fL vs. no CAM = 9.7 fL, P<0.001). Multivariate analysis showed that SGA, male sex and PIH were associated with PCT and PLT. This study demonstrates that different maternal and neonatal complications affect platelet parameters in late preterm and term neonates.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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