Combined Exercise Training and l-Glutamine Supplementation Enhances Both Humoral and Cellular Immune Responses after Influenza Virus Vaccination in Elderly Subjects.

Autor:	Monteiro FR; Department of Otorhinolaryngology, ENT Lab, Federal University of Sao Paulo (UNIFESP), Sao Paulo CEP 04025-002, Brazil.; Method Faculty of Sao Paulo (FAMESP), Sao Paulo CEP 04046-200, Brazil., Roseira T; Department of Otorhinolaryngology, ENT Lab, Federal University of Sao Paulo (UNIFESP), Sao Paulo CEP 04025-002, Brazil.; Method Faculty of Sao Paulo (FAMESP), Sao Paulo CEP 04046-200, Brazil., Amaral JB; Department of Otorhinolaryngology, ENT Lab, Federal University of Sao Paulo (UNIFESP), Sao Paulo CEP 04025-002, Brazil., Paixão V; Department of Otorhinolaryngology, ENT Lab, Federal University of Sao Paulo (UNIFESP), Sao Paulo CEP 04025-002, Brazil., Almeida EB; Department of Otorhinolaryngology, ENT Lab, Federal University of Sao Paulo (UNIFESP), Sao Paulo CEP 04025-002, Brazil., Foster R; Department of Otorhinolaryngology, ENT Lab, Federal University of Sao Paulo (UNIFESP), Sao Paulo CEP 04025-002, Brazil.; Method Faculty of Sao Paulo (FAMESP), Sao Paulo CEP 04046-200, Brazil., Sperandio A; Method Faculty of Sao Paulo (FAMESP), Sao Paulo CEP 04046-200, Brazil., Rossi M; Department of Otorhinolaryngology, ENT Lab, Federal University of Sao Paulo (UNIFESP), Sao Paulo CEP 04025-002, Brazil., Amirato GR; Department of Otorhinolaryngology, ENT Lab, Federal University of Sao Paulo (UNIFESP), Sao Paulo CEP 04025-002, Brazil., Apostólico JS; Department of Microbiology, Immunology and Parasitology, Federal University of Sao Paulo (UNIFESP/EPM), Sao Paulo CEP 04025-002, Brazil., Santos CAF; Department of Otorhinolaryngology, ENT Lab, Federal University of Sao Paulo (UNIFESP), Sao Paulo CEP 04025-002, Brazil., Felismino ES; Post-graduation Program in Health Science, Santo Amaro University (UNISA), Sao Paulo CEP 04829300, Brazil., Leal FB; Institute of Biomedical Science of University of Sao Paulo (USP), Sao Paulo CEP 05508-900, Brazil., Thomazelli LM; Institute of Biomedical Science of University of Sao Paulo (USP), Sao Paulo CEP 05508-900, Brazil., Durigon EL; Institute of Biomedical Science of University of Sao Paulo (USP), Sao Paulo CEP 05508-900, Brazil.; Scientific Platform Pasteur USP, Sao Paulo CEP 05508-020, Brazil., Oliveira DBL; Institute of Biomedical Science of University of Sao Paulo (USP), Sao Paulo CEP 05508-900, Brazil.; Hospital Israelita Albert Einstein, Sao Paulo CEP 05652-900, Brazil., Vieira RP; Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Sao Jose dos Campos CEP 12245-520, Brazil.; Post-graduation Program in Bioengineering and Biomedical Engineering, Universidade Brasil, Sao Paulo CEP 08230-030, Brazil.; Post-graduation Program in Science of Human and Rehabilitation, Federal University of Sao Paulo (UNIFESP), Santos CEP 11060-001, Brazil., Santos JMB; Post-graduation Program in Science of Human and Rehabilitation, Federal University of Sao Paulo (UNIFESP), Santos CEP 11060-001, Brazil., Bachi ALL; Department of Otorhinolaryngology, ENT Lab, Federal University of Sao Paulo (UNIFESP), Sao Paulo CEP 04025-002, Brazil.; Post-graduation Program in Health Science, Santo Amaro University (UNISA), Sao Paulo CEP 04829300, Brazil.; Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Sao Jose dos Campos CEP 12245-520, Brazil.
Jazyk:	angličtina
Zdroj:	Vaccines [Vaccines (Basel)] 2020 Nov 16; Vol. 8 (4). Date of Electronic Publication: 2020 Nov 16.
DOI:	10.3390/vaccines8040685
Abstrakt:	Background: Since aging affects the immune responses against vaccination, the present study evaluated the effects of L-glutamine (Gln) supplementation in the humoral and cellular immune responses in elderly subjects, practitioners or not, of physical exercise training. Methods: Eighty-four elderly people (aged 72.6 ± 6.1), non-practitioners (NP, n = 31), and practitioners of combined-exercise training (CET, n = 53) were submitted to Influenza virus vaccination and supplemented with Gln (0.3 g/kg of weight + 10 g of maltodextrin, groups: NP-Gln ( n = 14), and CET-Gln ( n = 26)), or placebo (10 g of maltodextrin, groups: NP-PL ( n = 17), and CET-PL ( n = 27)). Blood samples were collected pre (baseline) and 30 days post-vaccination and supplementation. Results: Comparing with the baseline values, whereas the NP-Gln and CET-PL groups showed higher specific-IgM levels, the CET-Gln group showed higher specific-IgM and IgA levels post-vaccination. The titer rate of hemagglutination inhibition was higher in the CET-Gln, NP-PL, and NP-Gln groups post-vaccination than baseline values. The absolute number of naive and effector CD4+ T cells was higher especially in the NP-Gln and CET-Gln groups, whilst activated CD4+ T cells were higher in CET subgroups post-vaccination. Conclusion: Our results showed that both l-glutamine supplementation and combined-exercise training can improve the immune responses to the Influenza virus vaccine in elderly subjects.
Databáze:	MEDLINE
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