Larvicide Activity on Aedes aegypti of Essential Oil Nanoemulsion from the Protium heptaphyllum Resin.

Autor: Faustino CG; Postgraduate Program of Pharmaceutical Innovation, Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil., de Medeiros FA; Postgraduate Program in Health Sciences, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil., Ribeiro Galardo AK; Institute of Scientific and Technological Research of the State of Amapá, Highway Juscelino Kubitschek, Km 10, Macapá 68903-419, Brazil., Lobato Rodrigues AB; Postgraduate Program in Biodiversity and Biotechnology Network BIONORTE, Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68902-280, Brazil., Lopes Martins R; Postgraduate Program in Biodiversity and Biotechnology Network BIONORTE, Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68902-280, Brazil., de Medeiros Souza Lima Y; Postgraduate Program in Health Sciences, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil., Fechine Tavares J; Postgraduate Program in Natural and Synthetic Products at the Federal University of Paraíba, Cidade Universitária, João Pessoa 58051-900, Brazil., Alves de Medeiros MA; Nova Esperança (FAMENE) School of Medicine, Frei Galvão, Gramame, João Pessoa 58067-695, Brazil.; Faculty of Medical Sciences of Paraíba (FCM) BR 230, Km 9, Intermares-Cabedelo, Paraíba 58310-000, Brazil., Dos Santos Cruz J; Postgraduate Program in Biochemistry and Immunology Federal University of Minas Gerais, Avenida Antônio Coelho, Minas Gerais 31270-901, Brazil., Almeida SSMDS; Postgraduate Program of Pharmaceutical Innovation, Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil.; Postgraduate Program in Biodiversity and Biotechnology Network BIONORTE, Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68902-280, Brazil.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2020 Nov 16; Vol. 25 (22). Date of Electronic Publication: 2020 Nov 16.
DOI: 10.3390/molecules25225333
Abstrakt: The aim of this work was to prepare a nanoemulsion containing the essential oil of Protium heptaphyllum resin and to evaluate the larvicidal activity and the residual larvicidal effect against Aedes aegypti. The essential oil was identified by gas chromatography coupled to a mass spectrometer, and the nanoemulsions were prepared using a low-energy method and characterized by photon correlation spectroscopy. The results indicated the major constituents as p -cimene (27.70%) and α-Pinene (22.31%). Nanoemulsions had kinetic stability and a monomodal distribution in a hydrophilic-lipophilic balance of 14 with particle diameters of 115.56 ± 1.68 nn and zeta potential of -29.63 ± 3.46 mV. The nanoemulsion showed larvicidal action with LC 50 = 2.91 µg∙mL -1 and residual larvicidal effect for 72 h after application to A. aegypti larvae. Consequently, the nanobiotechnological product derived from the essential oil of P. heptaphyllum resin could be used against infectious disease vectors.
Databáze: MEDLINE
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