Prostate Specific Membrane Antigen Positron Emission Tomography/Computerized Tomography in the Evaluation of Initial Response in Candidates Who Underwent Salvage Radiation Therapy after Radical Prostatectomy for Prostate Cancer.

Autor:	Meijer D; Amsterdam University Medical Center, VU University, Department of Urology, Prostate Cancer Network Amsterdam, Amsterdam, The Netherlands.; Amsterdam University Medical Center, VU University, Department of Radiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam, The Netherlands., Luiting HB; Erasmus University Medical Center, Department of Urology, Rotterdam, The Netherlands., van Leeuwen PJ; The Netherlands Cancer Institute, Department of Urology, Prostate Cancer Network Amsterdam, Amsterdam, The Netherlands., Remmers S; Erasmus University Medical Center, Department of Urology, Rotterdam, The Netherlands., Jansen BHE; Amsterdam University Medical Center, VU University, Department of Urology, Prostate Cancer Network Amsterdam, Amsterdam, The Netherlands.; Amsterdam University Medical Center, VU University, Department of Radiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam, The Netherlands., Bodar YJL; Amsterdam University Medical Center, VU University, Department of Urology, Prostate Cancer Network Amsterdam, Amsterdam, The Netherlands.; Amsterdam University Medical Center, VU University, Department of Radiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam, The Netherlands., Witteveen T; The Netherlands Cancer Institute, Department of Radiation Oncology, Amsterdam, The Netherlands., Schaake EE; The Netherlands Cancer Institute, Department of Radiation Oncology, Amsterdam, The Netherlands., van der Poel HG; The Netherlands Cancer Institute, Department of Urology, Prostate Cancer Network Amsterdam, Amsterdam, The Netherlands., Wondergem M; Noordwest Ziekenhuisgroep, Department of Nuclear Medicine, Alkmaar, The Netherlands., Busstra MB; Erasmus University Medical Center, Department of Urology, Rotterdam, The Netherlands., Nieuwenhuijzen JA; Amsterdam University Medical Center, VU University, Department of Urology, Prostate Cancer Network Amsterdam, Amsterdam, The Netherlands.; The Netherlands Cancer Institute, Department of Urology, Prostate Cancer Network Amsterdam, Amsterdam, The Netherlands., Meijnen P; Amsterdam University Medical Center, VU University, Department of Radiation Oncology, Cancer Center Amsterdam, Amsterdam, The Netherlands., Brabander T; Erasmus University Medical Center, Department of Radiology & Nuclear Medicine, Rotterdam, The Netherlands., van Moorselaar RJA; Amsterdam University Medical Center, VU University, Department of Urology, Prostate Cancer Network Amsterdam, Amsterdam, The Netherlands., Hendrikse NH; Amsterdam University Medical Center, VU University, Department of Radiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam, The Netherlands.; Amsterdam University Medical Center, VU University, Department of Clinical Pharmacology and Pharmacy, Amsterdam, The Netherlands., Oprea-Lager DE; Amsterdam University Medical Center, VU University, Department of Radiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam, The Netherlands., Roobol MJ; Erasmus University Medical Center, Department of Urology, Rotterdam, The Netherlands., Vis AN; Amsterdam University Medical Center, VU University, Department of Urology, Prostate Cancer Network Amsterdam, Amsterdam, The Netherlands.; The Netherlands Cancer Institute, Department of Urology, Prostate Cancer Network Amsterdam, Amsterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	The Journal of urology [J Urol] 2021 Apr; Vol. 205 (4), pp. 1100-1109. Date of Electronic Publication: 2020 Nov 18.
DOI:	10.1097/JU.0000000000001437
Abstrakt:	Purpose: We assessed predictors of short-term oncologic outcomes of patients who underwent salvage radiation therapy for biochemical recurrence after robot-assisted laparoscopic radical prostatectomy without evidence of metastases on prostate specific membrane antigen positron emission tomography/computerized tomography. Materials and Methods: We retrospectively analyzed 194 patients with biochemical recurrence after robot-assisted laparoscopic radical prostatectomy who underwent prostate specific membrane antigen positron emission tomography/computerized tomography prior to salvage radiation therapy. Patients with lymph node or distant metastases on restaging imaging or at the time of extended pelvic lymph node dissection during robot-assisted laparoscopic radical prostatectomy were excluded, as were patients who received androgen deprivation therapy during or prior to salvage radiation therapy. A multivariable logistic regression analysis was performed to assess predictors of treatment response, defined as prostate specific antigen value ≤0.1 ng/ml after salvage radiation therapy. Results: Overall treatment response after salvage radiation therapy was 75% (146/194 patients). On multivariable analysis, prostate specific antigen value at initiation of salvage radiation therapy (OR 0.42, 95% CI 0.27-0.62, p <0.001), pathological T stage (pT3a vs pT2 OR 0.28, 95% CI 0.11-0.69, p=0.006; pT3b vs pT2 OR 0.26, 95% CI 0.09-0.71, p=0.009) and local recurrent disease on imaging (OR 5.53, 95% CI 1.96-18.52, p=0.003) were predictors of treatment response. Conclusions: Salvage radiation therapy in patients without evidence of metastases on prostate specific membrane antigen positron emission tomography/computerized tomography showed a good overall treatment response of 75%. Higher treatment response rates were observed in patients with lower prostate specific antigen values at initiation of salvage radiation therapy, those with local recurrent disease on imaging and those with lower pathological T stage (pT2 vs pT3a/b).
Databáze:	MEDLINE
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