Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018.
| Autor: | Sousa IP Jr; Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Enterovírus, Rio de Janeiro, RJ, Brasil., Machado RS; Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Enterovírus, Rio de Janeiro, RJ, Brasil., Burlandy FM; Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Enterovírus, Rio de Janeiro, RJ, Brasil., Silva EED; Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Enterovírus, Rio de Janeiro, RJ, Brasil. |
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| Jazyk: | angličtina |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2020 Nov 13; Vol. 54, pp. e20190499. Date of Electronic Publication: 2020 Nov 13 (Print Publication: 2020). |
| DOI: | 10.1590/0037-8682-0499-2019 |
| Abstrakt: | Although different etiological agents can cause acute meningoencephalitis, this syndrome is usually associated with viruses. Among these, enteroviruses play a significant role. Here, we describe a fatal case of meningoencephalitis in a previously healthy teenager. Real-time RT-PCR and cell culture assays were performed with serum and cerebrospinal fluid (CSF) from a clinically diagnosed meningoencephalitis case that occurred in Rio de Janeiro State, Brazil. Coxsackievirus B2 (CVB2) was identified. Phylogenetic analysis revealed that the identified CVB2 was genetically related to strains known to cause neurological diseases. This case highlights the importance of continuous laboratory surveillance of central nervous system infections. |
| Databáze: | MEDLINE |
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