Early weight gain trajectories and body composition in infancy in infants born very preterm.

Autor: Beunders VAA; Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia's Children's Hospital, Rotterdam, The Netherlands., Roelants JA; Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia's Children's Hospital, Rotterdam, The Netherlands., Hulst JM; Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, Canada., Rizopoulos D; Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands., Hokken-Koelega ACS; Department of Pediatrics, Division of Pediatric Endocrinology, Erasmus MC-Sophia's Children's Hospital, Rotterdam, The Netherlands., Neelis EG; Department of Pediatrics, Division of Pediatric Gastroenterology, Erasmus MC-Sophia's Children's Hospital, Rotterdam, The Netherlands., de Fluiter KS; Department of Pediatrics, Division of Pediatric Endocrinology, Erasmus MC-Sophia's Children's Hospital, Rotterdam, The Netherlands., Jaddoe VWV; Department of Pediatrics, Erasmus MC-Sophia's Children's Hospital, Rotterdam, The Netherlands., Reiss IKM; Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia's Children's Hospital, Rotterdam, The Netherlands., Joosten KFM; Department of Pediatrics, Intensive Care Unit, Erasmus MC-Sophia's Children's Hospital, Rotterdam, The Netherlands., Vermeulen MJ; Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia's Children's Hospital, Rotterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Pediatric obesity [Pediatr Obes] 2021 Jun; Vol. 16 (6), pp. e12752. Date of Electronic Publication: 2020 Nov 17.
DOI: 10.1111/ijpo.12752
Abstrakt: Background: Concerns are raised about the influence of rapid growth on excessive fat mass (FM) gain in early life and later cardiometabolic health of infants born preterm.
Objectives: To study the association between postnatal weight gain trajectories and body composition in infancy in infants born very preterm.
Methods: In infants born <30 weeks gestation, we evaluated associations between weight Z-score trajectories for three consecutive timeframes (NICU stay, level-II hospital stay and at home) and body composition, measured at 2 and 6 months corrected age by air-displacement plethysmography.
Results: Of 120 infants included, median gestational age at birth was 27 +5 (interquartile range 26 +1 ;28 +5 ) and birth weight 1015 g (801;1250). The majority of infants did not make up for their initial loss of weight Z-score, but growth and later body composition were within term reference values. Weight gain during NICU stay was not associated with fat mass (absolute, %FM or FM index) in infancy. Weight gain during NICU and level II hospital stay was weakly associated with higher absolute lean mass (LM), but not after adjustment for length (LM index). Weight gain in the level-II hospital was positively associated with fat mass parameters at 2 months but not at 6 months. Strongest associations were found between weight gain at home and body composition (at both time points), especially fat mass.
Conclusions: Weight gain in different timeframes after preterm birth is associated with distinct parameters of body composition in infancy, with weight gain at home being most strongly related to fat mass.
(© 2020 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.)
Databáze: MEDLINE
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