Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial.

Autor: Simon SS; Old Age Research Group (PROTER) Department and Institute of Psychiatry Faculty of Medicine University of São Paulo São Paulo Brazil., Hampstead BM; Department of Psychiatry University of Michigan Ann Arbor Michigan USA.; Mental Health Service VA Ann Arbor Healthcare System Ann Arbor Michigan USA., Nucci MP; Neuroimagem Funcional (NIF) - Laboratory of Medical Investigations on Magnetic Resonance Imaging (LIM-44) Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de São Paulo São Paulo Brazil., Ferreira LK; Laboratory of Psychiatric Neuroimaging (LIM-21) Department and Institute of Psychiatry Faculty of Medicine University of São Paulo São Paulo Brazil., Duran FLS; Laboratory of Psychiatric Neuroimaging (LIM-21) Department and Institute of Psychiatry Faculty of Medicine University of São Paulo São Paulo Brazil., Fonseca LM; Old Age Research Group (PROTER) Department and Institute of Psychiatry Faculty of Medicine University of São Paulo São Paulo Brazil., Martin MDGM; Neuroimagem Funcional (NIF) - Laboratory of Medical Investigations on Magnetic Resonance Imaging (LIM-44) Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de São Paulo São Paulo Brazil., Ávila R; Old Age Research Group (PROTER) Department and Institute of Psychiatry Faculty of Medicine University of São Paulo São Paulo Brazil., Porto FHG; Old Age Research Group (PROTER) Department and Institute of Psychiatry Faculty of Medicine University of São Paulo São Paulo Brazil., Brucki SMD; Department of Neurology Faculty of Medicine University of São Paulo São Paulo Brazil., Martins CB; Department of Preventive Medicine Paulista School of Medicine Federal University of São Paulo São Paulo Brazil., Tascone LS; Old Age Research Group (PROTER) Department and Institute of Psychiatry Faculty of Medicine University of São Paulo São Paulo Brazil.; Laboratory of Psychiatric Neuroimaging (LIM-21) Department and Institute of Psychiatry Faculty of Medicine University of São Paulo São Paulo Brazil., Jr EA; Neuroimagem Funcional (NIF) - Laboratory of Medical Investigations on Magnetic Resonance Imaging (LIM-44) Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de São Paulo São Paulo Brazil., Busatto GF; Laboratory of Psychiatric Neuroimaging (LIM-21) Department and Institute of Psychiatry Faculty of Medicine University of São Paulo São Paulo Brazil., Bottino CMC; Old Age Research Group (PROTER) Department and Institute of Psychiatry Faculty of Medicine University of São Paulo São Paulo Brazil.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2020 Nov 06; Vol. 6 (1), pp. e12075. Date of Electronic Publication: 2020 Nov 06 (Print Publication: 2020).
DOI: 10.1002/trc2.12075
Abstrakt: Introduction: Mnemonic strategy training (MST) has been shown to improve cognitive performance and increase brain activation in those with mild cognitive impairment (MCI). However, little is known regarding the effects of MST on functional connectivity (FC) at rest. The aim of the present study was to investigate the MST focused on face-name associations effect on resting-state FC in those with MCI.
Methods: Twenty-six amnestic MCI participants were randomized in MST (N = 14) and Education Program (active control; N = 12). Interventions occurred twice a week over two consecutive weeks (ie, four sessions). Resting-state functional magnetic resonance imaging was collected at pre- and post-intervention. Regions of interest (ROIs) were selected based on areas that previously showed task-related activation changes after MST. Changes were examined through ROI-to-ROI analysis and significant results were corrected for multiple comparisons.
Results: At post-intervention, only the MST group showed increased FC, whereas the control group showed decreased or no change in FC. After MST, there was an increased FC between the left middle temporal gyrus and right orbitofrontal cortex. In addition, a time-by-group interaction indicated that the MST group showed greater increased FC between the right inferior frontal gyrus and left brain regions, such as fusiform gyrus, temporal pole, and orbitofrontal cortex relative to controls.
Discussion: MST enhanced FC in regions that are functionally relevant for the training; however, not in all ROIs investigated. Our findings suggest that MST-induced changes are reflected in task-specific conditions, as previously reported, but also in general innate connectivity. Our results both enhance knowledge about the mechanisms underlying MST effects and may provide neurophysiological evidence of training transfer.
Competing Interests: No author has any conflict of interest.
(© 2020 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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