Phthalates in the diet of Mexican children of school age. Risk analysis.

Autor:	García-Fabila MM; Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón and Paseo Tollocan SN., Colonia Ocho Cedros, Toluca, Estado de México, C.P. 50120, Mexico., Chávez AA; Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón and Paseo Tollocan SN., Colonia Ocho Cedros, Toluca, Estado de México, C.P. 50120, Mexico., Meza JCS; Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón and Paseo Tollocan SN., Colonia Ocho Cedros, Toluca, Estado de México, C.P. 50120, Mexico., Montes LPB; Decanato de Ciencias de la Salud, Universidad Autónoma de Guadalajara, Av. Montevideo esquina Avenida Acueducto, Guadalajara, Jalisco, CP 44670, Mexico., García AR; Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón and Paseo Tollocan SN., Colonia Ocho Cedros, Toluca, Estado de México, C.P. 50120, Mexico.
Jazyk:	angličtina
Zdroj:	Toxicology reports [Toxicol Rep] 2020 Oct 29; Vol. 7, pp. 1487-1494. Date of Electronic Publication: 2020 Oct 29 (Print Publication: 2020).
DOI:	10.1016/j.toxrep.2020.10.020
Abstrakt:	Phthalates are widely used as plasticizers, additives, or solvents. Its extensive use has generated environmental and food contamination, which implies continuous population exposure. The aim of this work was to determine the probability of health risk of Mexican children exposed to phthalates through the consumption of contaminated food. A survey was applied to 384 Mexican school-age children (between 6 and 12 years old), to find out the type of food they eat most frequently, based on this, a research was made to know the concentration of phthalates contained in these foods. The daily intake had been calculated with the concentration of phthalates reported in food, obtaining: DEHP (19.50 μg/kg body weight/day), DnBP (5.52 μg/kg body weight/day) y for DEP (1.12 μg/kg body weight/day). The hazard index (HI) for DEP y DEHP was 0.49 to 42.5 for internal organs damage reported. HI for reproductive health damage due to exposure to DnBT and DEHP was of 0.04 to 5.58, so that there is a high probability that children's health is at risk. Therefore, it is necessary to a quantitative analysis of phthalates in food consumed in Latin American countries and establish the TDI of phthalates especially, to DEHP, which was obtained the higher HI. Competing Interests: The authors report no declarations of interest. (© 2020 Elsevier B.V.)
Databáze:	MEDLINE
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