| Autor: |
Druckenbrod NR; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA, 02115, USA.; Decibel Therapeutics, 1325 Boylston St #500, Boston, MA, 02215, USA., Hale EB; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA, 02115, USA., Olukoya OO; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA, 02115, USA., Shatzer WE; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA, 02115, USA., Goodrich LV; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA, 02115, USA. Lisa_Goodrich@hms.harvard.edu. |
| Abstrakt: |
In the developing nervous system, axons navigate through complex terrains that change depending on when and where outgrowth begins. For instance, in the developing cochlea, spiral ganglion neurons extend their peripheral processes through a growing and heterogeneous environment en route to their final targets, the hair cells. Although the basic principles of axon guidance are well established, it remains unclear how axons adjust strategies over time and space. Here, we show that neurons with different positions in the spiral ganglion employ different guidance mechanisms, with evidence for both glia-guided growth and fasciculation along a neuronal scaffold. Processes from neurons in the rear of the ganglion are more directed and grow faster than those from neurons at the border of the ganglion. Further, processes at the wavefront grow more efficiently when in contact with glial precursors growing ahead of them. These findings suggest a tiered mechanism for reliable axon guidance. |
