Sex differences in prevalence of migraine trigger factors: A cross-sectional study.

Autor: van Casteren DS; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.; Division of Vascular Medicine and Pharmacology, Erasmus University Medical Center, Rotterdam, The Netherlands., Verhagen IE; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.; Division of Vascular Medicine and Pharmacology, Erasmus University Medical Center, Rotterdam, The Netherlands., Onderwater GL; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands., MaassenVanDenBrink A; Division of Vascular Medicine and Pharmacology, Erasmus University Medical Center, Rotterdam, The Netherlands., Terwindt GM; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk: angličtina
Zdroj: Cephalalgia : an international journal of headache [Cephalalgia] 2021 May; Vol. 41 (6), pp. 643-648. Date of Electronic Publication: 2020 Nov 17.
DOI: 10.1177/0333102420974362
Abstrakt: Aim: To examine the effect of sex on migraine trigger factors.
Methods: Prevalence of 11 frequently reported trigger factors was determined in a cross-sectional study among migraine patients from a validated migraine database (n = 5725 females and n = 1061 males). Female-to-male odds ratios were calculated for each trigger, using a logistic regression model with attack frequency and migraine subtype (with or without aura) as covariates. Additionally, the effect of sex on total number of triggers per individual was determined.
Results: The top three most reported triggers in women were menstruation (78%), stress (77%), and bright light (69%). Men reported stress (69%), bright light (63%), and sleep deprivation (60%) most frequently as provoking factors. The following triggers were more often reported by women than men: Bright light (odds ratio 1.29 [95% CI 1.12-1.48]; p  = 0.003), stress (1.47 [1.27-1.69]; p  < 0.001), skipping a meal (1.24 [1.09-1.42]; p  = 0.015), sleep deprivation (1.37 [1.20-1.57]; p  < 0.001), high altitudes (1.70 [1.40-2.09]; p  < 0.001), and weather changes (1.35 [1.18-1.55]; p  < 0.001). Women reported more triggers than men, even when menstruation was disregarded (mean ± SD: 4.6 ± 2.3 and 4.3 ± 2.3; p  < 0.001). Conclusion: Women report migraine trigger factors to be provocative of their attacks more frequently than men, which may be related to a lower migraine threshold due to sex hormonal changes.
Databáze: MEDLINE
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