Enteroviruses from Humans and Great Apes in the Republic of Congo: Recombination within Enterovirus C Serotypes.

Autor: Amona I; IHU Méditerranée Infection, CEDEX 05, 13005 Marseille, France.; IRD, SSA, APHM, VITROME, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.; Faculté des Sciences et Techniques, Université Marien NGOUABI, Brazzaville, Congo., Medkour H; IHU Méditerranée Infection, CEDEX 05, 13005 Marseille, France.; IRD, AP-HM, MEPHI, Aix Marseille University, 13385 Marseille, France.; PADESCA Laboratory, Veterinary Science Institute, University Constantine 1, El Khroub 25100, Algeria., Akiana J; Laboratoire National de Santé Publique, Brazzaville, Congo., Davoust B; IHU Méditerranée Infection, CEDEX 05, 13005 Marseille, France.; IRD, AP-HM, MEPHI, Aix Marseille University, 13385 Marseille, France., Tall ML; IHU Méditerranée Infection, CEDEX 05, 13005 Marseille, France.; IRD, AP-HM, MEPHI, Aix Marseille University, 13385 Marseille, France., Grimaldier C; IHU Méditerranée Infection, CEDEX 05, 13005 Marseille, France., Gazin C; IHU Méditerranée Infection, CEDEX 05, 13005 Marseille, France., Zandotti C; IHU Méditerranée Infection, CEDEX 05, 13005 Marseille, France., Levasseur A; IHU Méditerranée Infection, CEDEX 05, 13005 Marseille, France.; IRD, AP-HM, MEPHI, Aix Marseille University, 13385 Marseille, France., Scola B; IHU Méditerranée Infection, CEDEX 05, 13005 Marseille, France.; IRD, AP-HM, MEPHI, Aix Marseille University, 13385 Marseille, France., Raoult D; IHU Méditerranée Infection, CEDEX 05, 13005 Marseille, France.; IRD, AP-HM, MEPHI, Aix Marseille University, 13385 Marseille, France., Fenollar F; IHU Méditerranée Infection, CEDEX 05, 13005 Marseille, France.; IRD, SSA, APHM, VITROME, Aix-Marseille University, CEDEX 05, 13385 Marseille, France., Banga-Mboko H; Ecole Nationale d'Agronomie et de Foresterie, Université Marien NGOUABI, Brazzaville, Congo., Mediannikov O; IHU Méditerranée Infection, CEDEX 05, 13005 Marseille, France.; IRD, AP-HM, MEPHI, Aix Marseille University, 13385 Marseille, France.
Jazyk: angličtina
Zdroj: Microorganisms [Microorganisms] 2020 Nov 13; Vol. 8 (11). Date of Electronic Publication: 2020 Nov 13.
DOI: 10.3390/microorganisms8111779
Abstrakt: Enteroviruses (EVs) are viruses of the family Picornaviridae that cause mild to severe infections in humans and in several animal species, including non-human primates (NHPs). We conducted a survey and characterization of enteroviruses circulating between humans and great apes in the Congo. Fecal samples (N = 24) of gorillas and chimpanzees living close to or distant from humans in three Congolese parks were collected, as well as from healthy humans (N = 38) living around and within these parks. Enteroviruses were detected in 29.4% of gorilla and 13.15% of human feces, including wild and human-habituated gorillas, local humans and eco-guards. Two identical strains were isolated from two humans coming from two remote regions. Their genomes were similar and all genes showed their close similarity to coxsackieviruses, except for the 3C, 3D and 5'-UTR regions, where they were most similar to poliovirus 1 and 2, suggesting recombination. Recombination events were found between these strains, poliovirus 1 and 2 and EV-C99. It is possible that the same EV-C species circulated in both humans and apes in different regions in the Congo, which must be confirmed in other investigations. In addition, other studies are needed to further investigate the circulation and genetic diversity of enteroviruses in the great ape population, to draw a definitive conclusion on the different species and types of enteroviruses circulating in the Republic of Congo.
Databáze: MEDLINE
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