Pharmacokinetic, pharmacodynamic, and pharmacogenetic assays to monitor clopidogrel therapy.
| Autor: | Alvitigala BY; Department of Medical Laboratory Science, Faculty of Health Sciences, The Open University of Sri Lanka, Nugegoda, Sri Lanka., Gooneratne LV; Department of Pathology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka., Constantine GR; Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka., Wijesinghe RANK; Department of Clinical Sciences, Faculty of Medicine, General Sir John Kotelawala Defense University, Ratmalana, Sri Lanka., Arawwawala LDAM; Research & Development Complex, Industrial Technology Institute, Malabe, Sri Lanka. |
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| Jazyk: | angličtina |
| Zdroj: | Pharmacology research & perspectives [Pharmacol Res Perspect] 2020 Dec; Vol. 8 (6), pp. e00686. |
| DOI: | 10.1002/prp2.686 |
| Abstrakt: | Clopidogrel is the most common and widely used antiplatelet agent for patients with coronary artery disease following confirmation by electrocardiographic studies. The nonresponsiveness of patients to clopidogrel and the possibility of testing for clopidogrel resistance by platelet function assays (PFA) are contentious issues. Light transmission aggregometry (LTA) is considered as the gold standard test among all PFA. In this review, the most commonly used PFA used for monitoring the effect of clopidogrel, LTA, vasodilator-stimulated phosphoprotein assay phosphorylation, rotational thromboelastometry (ROTEM) delta and ROTEM platelet, thromboelastography, PFA-100, VerifyNow P2Y12 assay, Multiplate analyzer, Plateletworks assay and pharmacogenetic studies, are comparatively discussed including their principles of action, advantages, and disadvantages. VerifyNow P2Y12 assay can be accepted as the ideal point of care test out of the discussed assays. However, modified assays are required which could overcome the limitations associated with currently available assays. (© 2020 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd.) |
| Databáze: | MEDLINE |
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