Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease.

Autor:	Montal V; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Vilaplana E; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Pegueroles J; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Bejanin A; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Alcolea D; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Carmona-Iragui M; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.; Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona, Spain., Clarimón J; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Levin J; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Cruchaga C; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; The Hope Center for Neurological Disorders, St. Louis, Missouri, USA.; NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, Missouri, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA., Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Noble JM; Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA., Lee JH; Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Allegri R; Department of Cognitive Neurology, Institute for Neurological Research Fleni, Buenos Aires, Argentina., Karch CM; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA., Laske C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Schofield PR; Neuroscience Research Australia, Sydney, Australia.; School of Medical Sciences, University of New South Wales, Sydney, Australia., Salloway S; Neurology and the Memory and Aging Program, Butler Hospital, Providence, Rhode Island, USA., Ances B; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; The Hope Center for Neurological Disorders, St. Louis, Missouri, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Radiology, Washington University in St. Louis, St. Louis, Missouri, USA., Benzinger T; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Radiology, Washington University in St. Louis, St. Louis, Missouri, USA., McDale E; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA., Bateman R; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; The Hope Center for Neurological Disorders, St. Louis, Missouri, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA., Blesa R; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Sánchez-Valle R; Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Fundació Clínic per a la Recerca Biomèdica, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain., Lleó A; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Fortea J; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.; Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2021 Apr; Vol. 17 (4), pp. 618-628. Date of Electronic Publication: 2020 Nov 16.
DOI:	10.1002/alz.12224
Abstrakt:	Introduction: A biphasic model for brain structural changes in preclinical Alzheimer's disease (AD) could reconcile some conflicting and paradoxical findings in observational studies and anti-amyloid clinical trials. Methods: In this study we tested this model fitting linear versus quadratic trajectories and computed the timing of the inflection points vertexwise of cortical thickness and cortical diffusivity-a novel marker of cortical microstructure-changes in 389 participants from the Dominantly Inherited Alzheimer Network. Results: In early preclinical AD, between 20 and 15 years before estimated symptom onset, we found increases in cortical thickness and decreases in cortical diffusivity followed by cortical thinning and cortical diffusivity increases in later preclinical and symptomatic stages. The inflection points 16 to 19 years before estimated symptom onset are in agreement with the start of tau biomarker alterations. Discussion: These findings confirm a biphasic trajectory for brain structural changes and have direct implications when interpreting magnetic resonance imaging measures in preventive AD clinical trials. (© 2020 the Alzheimer's Association.)
Databáze:	MEDLINE
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