Brazilian Consortium for the Study on Renal Diseases Associated With COVID-19: A Multicentric Effort to Understand SARS-CoV-2-Related Nephropathy.

Autor:	Teixeira Júnior AAL; Postgraduate Program in Genetics, Ribeirão Preto Medical School, University of São Paulo (PGGEN-FMRP-USP), Ribeirão Preto, Brazil.; University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil.; Clinical Research Center (CEPEC), University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil., Neves PDMM; Nephrology Division, Medical School, University of São Paulo (FM-USP), São Paulo, Brazil.; Molecular Medicine Discipline, Medical School, University of São Paulo (FM-USP), São Paulo, Brazil.; Nephrology and Dialysis Center, Oswaldo Cruz German Hospital, São Paulo, Brazil., Lages JS; University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil., Cunha KA; University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil.; Nephrology Service, University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil., Muniz MPR; University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil.; Nephrology Service, University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil., Brito DJA; University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil.; Nephrology Service, University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil., Watanabe A; Nephrology Division, Medical School, University of São Paulo (FM-USP), São Paulo, Brazil.; Molecular Medicine Discipline, Medical School, University of São Paulo (FM-USP), São Paulo, Brazil., Watanabe EH; Nephrology Division, Medical School, University of São Paulo (FM-USP), São Paulo, Brazil.; Molecular Medicine Discipline, Medical School, University of São Paulo (FM-USP), São Paulo, Brazil., Onuchic LF; Nephrology Division, Medical School, University of São Paulo (FM-USP), São Paulo, Brazil.; Molecular Medicine Discipline, Medical School, University of São Paulo (FM-USP), São Paulo, Brazil., Nunes LLA; University Hospital Complex, João de Barros Barreto University Hospital, Federal University of Pará (HUJBB - UFPA), Belém, Brazil., Coutinho Filho AF; Dr. Raimundo Bezerra Unit of Dialysis and Kidney Transplantation (UNIRIM), Crato, Brazil., Barcelos FL; Nephrology Service, University Hospital of Brasilia, University of Brasília (HUB - UNB), Brasília, Brazil., Gatto GC; Nephrology Service, University Hospital of Brasilia, University of Brasília (HUB - UNB), Brasília, Brazil., Monteiro A; Maria Aparecida Pedrossian University Hospital, Federal University of Mato Grosso do Sul (HUMAP - UFMS), Campo Grande, Brazil., Polido DDA; University Hospital, Federal University of Grande Dourados (HU-UFGD), Dourados, Brazil., Motta DRMS; Nephrology Service, University Hospital of the Federal University of Sergipe (HU-UFS), Aracaju, Brazil., Leite TO; Nephrology Service, University Hospital of Lizard, Federal University of Sergipe (HUL - UFS), Lagarto, Brazil., Guedes FL; Nephrology Service, Onofre Lopes University Hospital, Federal University of Rio Grande do Norte (HUOL-UFRN), Natal, Brazil., Gomes OV; University Hospital, Federal University of Vale do São Francisco (HU-UNIVASF), Petrolina, Brazil., Valente LM; Faculty of Medicine, Federal University of Pernambuco (UFPE), Recife, Brazil., Israel KCSP; Postgraduate Program in Tropical Medicine (FMT/UEA), Department of Clinical Medicine, Federal University of Amazonas (UFAM), Manaus, Brazil., Ladchumananandasivam FR; Nephrology Service, Lauro Wanderley University Hospital, Federal University of Paraíba (HULW-UFPB), João Pessoa, Brazil., de Farias LCL; Medical Clinic Unit, Hospital Universitário Alcides Carneiro (HUAC), Campina Grande, Brazil., Marques IDB; Nephrology Service, University Hospital, Federal University of Piauí (HU-UFPI), Teresina, Brazil., Uliano GL; School-Hospital, Federal University of Pelotas (HE-UFPEL), Pelotas, Brazil., Maramaldo CEC; Laboratory of Immunology and Microbiology of Respiratory Infections (LIMIR), Maranhão University Center (CEUMA), São Luís, Brazil., Neto LGL; Laboratory of Immunology and Microbiology of Respiratory Infections (LIMIR), Maranhão University Center (CEUMA), São Luís, Brazil., Luchi WM; Nephrology Service, Cassiano Antonio Moraes University Hospital, Federal University of Espírito Santo (HUCAM-UFES), Vitória, Brazil., Wanderley DC; Nephropathology Institute, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil., Araújo SA; Nephropathology Institute, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil., Salgado Filho N; University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil.; Nephrology Service, University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil., Silva GEB; University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil.; Nephrology Service, University Hospital, Federal University of Maranhão (HU-UFMA), São Luís, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2020 Oct 23; Vol. 7, pp. 584235. Date of Electronic Publication: 2020 Oct 23 (Print Publication: 2020).
DOI:	10.3389/fmed.2020.584235
Abstrakt:	Kidney involvement appears to be frequent in coronavirus disease 2019 (COVID-19). Despite this, information concerning renal involvement in COVID-19 is still scarce. Several mechanisms appear to be involved in the complex relationship between the virus and the kidney. Also, different morphological patterns have been described in the kidneys of patients with COVID-19. For some authors, however, this association may be just a coincidence. To investigate this issue, we propose assessing renal morphology associated with COVID-19 at the renal pathology reference center of federal university hospitals in Brazil. Data will come from a consortium involving 17 federal university hospitals belonging to Empresa Brasileira de Serviços Hospitalares (EBSERH) network, as well as some state hospitals and an autopsy center. All biopsies will be sent to the referral center for renal pathology of the EBSERH network. The data will include patients who had coronavirus disease, both alive and deceased, with or without pre-existing kidney disease. Kidney biopsies will be analyzed by light, fluorescence, and electron microscopy. Furthermore, immunohistochemical (IHC) staining for various inflammatory cells (i.e., cells expressing CD3, CD20, CD4, CD8, CD138, CD68, and CD57) as well as angiotensin-converting enzyme 2 (ACE2) will be performed on paraffinized tissue sections. In addition to ultrastructural assays, in situ hybridization (ISH), IHC and reverse transcription-polymerase chain reaction (RT-PCR) will be used to detect Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) in renal tissue. For the patients diagnosed with Collapsing Glomerulopathy, peripheral blood will be collected for apolipoprotein L-1 (APOL1) genotyping. For patients with thrombotic microangiopathy, thrombospondin type 1 motif, member 13 (ADAMTS13), antiphospholipid, and complement panel will be performed. The setting of this study is Brazil, which is second behind the United States in highest confirmed cases and deaths. With this complete approach, we hope to help define the spectrum and impact, whether immediate or long-term, of kidney injury caused by SARS-CoV-2. (Copyright © 2020 Teixeira Júnior, Neves, Lages, Cunha, Muniz, Brito, Watanabe, Watanabe, Onuchic, Nunes, Coutinho Filho, Barcelos, Gatto, Monteiro, Polido, Motta, Leite, Guedes, Gomes, Valente, Israel, Ladchumananandasivam, de Farias, Marques, Uliano, Maramaldo, Neto, Luchi, Wanderley, Araújo, Salgado Filho and Silva.)
Databáze:	MEDLINE
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