Evaluation of Serum Interleukin 6, Tumor Necrosis Factor-Alpha, and Interferon-Gamma Levels in Relation to Body Mass Index and Blood Pressure in HIV Seropositive Pregnant Women Coinfected with Malaria.

Autor: Chukwuagwu IU; Department of Medical Laboratory, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, PMB 5025, Nnewi, Anambra State, Nigeria., Ukibe NR; Department of Medical Laboratory, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, PMB 5025, Nnewi, Anambra State, Nigeria., Ogbu II; Department of Medical Laboratory, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, PMB 5025, Nnewi, Anambra State, Nigeria., Ikimi CG; Department of Biochemistry, Faculty of Science, Federal University of Otuoke, Yenagoa, Beyalsa State, Nigeria., Agu VO; Department of Medical Laboratory, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, PMB 5025, Nnewi, Anambra State, Nigeria., Kalu OA; Department of Medicine, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, PMB 5025, Nnewi, Anambra State, Nigeria., Ukibe SN; Department of Medical Microbiology, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, PMB 5025, Nnewi, Anambra State, Nigeria., Awalu JC; Department of Medical Laboratory, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, PMB 5025, Nnewi, Anambra State, Nigeria.
Jazyk: angličtina
Zdroj: Interdisciplinary perspectives on infectious diseases [Interdiscip Perspect Infect Dis] 2020 Oct 28; Vol. 2020, pp. 2424802. Date of Electronic Publication: 2020 Oct 28 (Print Publication: 2020).
DOI: 10.1155/2020/2424802
Abstrakt: Malaria and HIV are leading causes of morbidity and mortality, particularly in sub-Saharan Africa. Both diseases are highly endemic and have a wide geographic overlap with severe impact on pregnancy. This was a case-control study designed to evaluate the levels of interleukin -6 (IL-6), tumor necrosis factor-alpha (TNF- α ), and interferon-gamma (IFN- γ ) and their relationship with some anthropometric indices such as body mass index (BMI) and blood pressure in HIV-malaria coinfected women attending antenatal clinic at Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria. 122 pregnant women and 30 nonpregnant women (control) aged between 18 and 42 years were recruited for the study. Screening of HIV antibodies was done using a national algorithm. Peripheral malaria was determined using rapid detection and the Giemsa stain technique. Cytokines were assayed using the enzyme-linked immunosorbent assay technique. HIV-malaria coinfected pregnant women showed significantly higher levels of IL-6, IFN- γ , TNF- α , and blood pressure with reduced BMI value compared with HIV seronegative pregnant and nonpregnant control participants ( p ≤ 0.001, respectively). The findings indicated significant cytokine imbalance which suggests an active inflammatory process and reduced cellular immunity. The increased BMI and blood pressure level observed indicate overweight and possible hypertension which could subsequently lead to preeclampsia and other adverse pregnancy outcomes.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2020 Ikechukwu Uzoma Chukwuagwu et al.)
Databáze: MEDLINE
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