COVID-19 Infection in Men on Testosterone Replacement Therapy.

Autor:	Rambhatla A; Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA. Electronic address: Arambha1@hfhs.org., Bronkema CJ; School of Medicine, Wayne State University, Detroit, MI, USA; Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Detroit, MI, USA., Corsi N; School of Medicine, Wayne State University, Detroit, MI, USA; Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Detroit, MI, USA., Keeley J; Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Detroit, MI, USA., Sood A; Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA; Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Detroit, MI, USA., Affas Z; Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Detroit, MI, USA., Dabaja AA; Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA., Rogers CG; Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA., Liroff SA; Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA., Abdollah F; Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA; Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Detroit, MI, USA.
Jazyk:	angličtina
Zdroj:	The journal of sexual medicine [J Sex Med] 2021 Jan; Vol. 18 (1), pp. 215-218. Date of Electronic Publication: 2020 Oct 09.
DOI:	10.1016/j.jsxm.2020.09.013
Abstrakt:	Background: Men who contract coronavirus disease 2019 (COVID-19) appear to have worse clinical outcomes compared with women which raises the possibility of androgen-dependent effects. Aim: We sought to determine if testosterone replacement therapy (TRT) is associated with worse clinical outcomes. Methods: Through a retrospective chart review, we identified 32 men diagnosed with COVID-19 and on TRT. They were propensity score matched to 63 men diagnosed with COVID-19 and not on TRT. Data regarding comorbidities and endpoints such as hospital admission, intensive care unit admission, ventilator utilization, thromboembolic events, and death were extracted. Chi-square and Kruskal-Wallis tests examined differences in categorical and continuous variables, respectively. Logistic regression analysis tested the relationship between TRT status and the study endpoints. Results: There were no statistically significant differences between the 2 groups, and TRT was not a predictor of any of the endpoints on multivariate analysis. Conclusion: These results suggest that TRT is not associated with a worse clinical outcome in men diagnosed with COVID-19. Rambhatla A, Bronkema CJ, Corsi N, et al. COVID-19 Infection in Men on Testosterone Replacement Therapy. J Sex Med 2021;18:215-218. (Copyright © 2020 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu