Effectiveness of doxycycline for the treatment of zoonotic cutaneous leishmaniasis in vivo .

Autor:	Akulinina IK; Department of Biology and General Genetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Molodogvardeiskaya str., 34-263, Moscow121351, Russian Federation.; Department of Dermatology, University of Pisa, Via Roma, 67, Pisa56126, Italy., Berechikidze IA; Department of Biology and General Genetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Molodogvardeiskaya str., 34-263, Moscow121351, Russian Federation., Larina SN; Department of Biology and General Genetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Molodogvardeiskaya str., 34-263, Moscow121351, Russian Federation., Sakharova TV; Department of Biology and General Genetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Molodogvardeiskaya str., 34-263, Moscow121351, Russian Federation., Degtyarevskaya TY; Department of Biology and General Genetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Molodogvardeiskaya str., 34-263, Moscow121351, Russian Federation., Romanelli M; Department of Dermatology, University of Pisa, Via Roma, 67, Pisa56126, Italy.
Jazyk:	angličtina
Zdroj:	Parasitology [Parasitology] 2021 Mar; Vol. 148 (3), pp. 361-365. Date of Electronic Publication: 2020 Nov 16.
DOI:	10.1017/S0031182020002152
Abstrakt:	There are available data on in vivo studies of monotherapy of zoonotic cutaneous leishmaniasis with some antibacterial drugs (doxycycline) and their comparison with meglumine antimoniate (glucantime). We used golden Syrian hamsters as a laboratory model. Experimental groups were formed, each of which was treated with one of the tested drugs. Infection of animals was carried out with Leishmania major promastigotes. We selected highly virulent strains of L. major culture isolated from human ulcers or rodents. Meglumine antimoniate monotherapy and doxycycline monotherapy are quite effective and do not differ by the 30th day of their use in such indicators as the average degree of local damage and the average number of Leishmania in the lesions. The main differences were recorded in terms of average body weight gain and average clinical recovery in favour of doxycycline. Leishmania in the lesion on the 60th day were completely absent in treatment with doxycycline. The experiment proved the effectiveness of doxycycline monotherapy: Leishmania in the lesions were absolutely absent by the end of the treatment.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu