IBDs and the pediatric age: Their peculiarities and the involvement of the microbiota.

Autor: Cococcioni L; Department of Pediatrics, Vittore Buzzi Children's Hospital, Università di Milano, Italy., Panelli S; 'L. Sacco' Department of Biomedical and Clinical Sciences and Pediatric Clinical Research Center 'Romeo ed Enrica Invernizzi', Università di Milano, Italy. Electronic address: simona.panelli1@unimi.it., Varotto-Boccazzi I; Department of Biosciences, Università di Milano, Italy., Carlo DD; Department of Biosciences and Pediatric Clinical Research Center 'Romeo ed Enrica Invernizzi', Università di Milano, Italy., Pistone D; Department of Biomedical Sciences for Health, University di Milano, Italy., Leccese G; Department of Biosciences, Università di Milano, Italy., Zuccotti GV; Department of Pediatrics, Vittore Buzzi Children's Hospital, Università di Milano, Italy; 'L. Sacco' Department of Biomedical and Clinical Sciences and Pediatric Clinical Research Center 'Romeo ed Enrica Invernizzi', Università di Milano, Italy., Comandatore F; 'L. Sacco' Department of Biomedical and Clinical Sciences and Pediatric Clinical Research Center 'Romeo ed Enrica Invernizzi', Università di Milano, Italy.
Jazyk: angličtina
Zdroj: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2021 Jan; Vol. 53 (1), pp. 17-25. Date of Electronic Publication: 2020 Nov 11.
DOI: 10.1016/j.dld.2020.10.033
Abstrakt: Inflammatory Bowel Diseases (IBDs) are gastrointestinal disorders characterized by chronic, relapsing inflammation, with growing incidence worldwide over the last decades and distinctive features in the pediatric age. An increasing body of evidence indicates that gut microbiota plays a major role in inflammatory disorders, including IBDs. In this review we will discuss the most recent evidences on dysbiotic changes associated with gut inflammation, as well as environmental and genetic factors contributing to IBD pathogenesis, with a focus on the peculiarities of the pediatric age.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interests
(Copyright © 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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