Central Amygdala Projections to Lateral Hypothalamus Mediate Avoidance Behavior in Rats.

Autor:	Weera MM; Department of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 mweera@lsuhsc.edu., Shackett RS; Department of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112., Kramer HM; Department of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112., Middleton JW; Department of Cell Biology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.; Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.; Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112., Gilpin NW; Department of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.; Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.; Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.; Southeast Louisiana VA Healthcare System (SLVHCS), New Orleans, Louisiana 70119.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Jan 06; Vol. 41 (1), pp. 61-72. Date of Electronic Publication: 2020 Nov 13.
DOI:	10.1523/JNEUROSCI.0236-20.2020
Abstrakt:	Persistent avoidance of stress-related stimuli following acute stress exposure predicts negative outcomes such as substance abuse and traumatic stress disorders. Previous work using a rat model showed that the central amygdala (CeA) plays an important role in avoidance of a predator odor stress-paired context. Here, we show that CeA projections to the lateral hypothalamus (LH) are preferentially activated in male rats that show avoidance of a predator odor-paired context (termed Avoider rats), that chemogenetic inhibition of CeA-LH projections attenuates avoidance in male Avoider rats, that chemogenetic stimulation of the CeA-LH circuit produces conditioned place avoidance (CPA) in otherwise naive male rats, and that avoidance behavior is associated with intrinsic properties of LH-projecting CeA cells. Collectively, these data show that CeA-LH projections are important for persistent avoidance of stress-related stimuli following acute stress exposure. SIGNIFICANCE STATEMENT This study in rats shows that a specific circuit in the brain [i.e., neurons that project from the central amygdala (CeA) to the lateral hypothalamus (LH)] mediates avoidance of stress-associated stimuli. In addition, this study shows that intrinsic physiological properties of cells in this brain circuit are associated with avoidance of stress-associated stimuli. Further characterization of the CeA-LH circuit may improve our understanding of the neural mechanisms underlying specific aspects of stress-related disorders in humans. (Copyright © 2021 the authors.)
Databáze:	MEDLINE
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