Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm.

Autor:	Mudd PA; Department of Emergency Medicine, Washington University School of Medicine, Saint Louis, MO, USA. pmudd@wustl.edu paul.thomas@stjude.org ellebedy@wustl.edu., Crawford JC; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Turner JS; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA., Souquette A; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Reynolds D; Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Bender D; Bursky Center for Human Immunology and Immunotherapy Program, Washington University School of Medicine, Saint Louis, MO, USA., Bosanquet JP; Department of Critical Care, Missouri Baptist Medical Center, Saint Louis, MO, USA., Anand NJ; Department of Critical Care, Missouri Baptist Medical Center, Saint Louis, MO, USA., Striker DA; Department of Critical Care, Missouri Baptist Medical Center, Saint Louis, MO, USA., Martin RS; Department of Critical Care, Missouri Baptist Medical Center, Saint Louis, MO, USA., Boon ACM; Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA., House SL; Department of Emergency Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Remy KE; Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.; Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO, USA.; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA., Hotchkiss RS; Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.; Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA., Presti RM; Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA., O'Halloran JA; Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Powderly WG; Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Thomas PG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA. pmudd@wustl.edu paul.thomas@stjude.org ellebedy@wustl.edu., Ellebedy AH; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA. pmudd@wustl.edu paul.thomas@stjude.org ellebedy@wustl.edu.; Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.; Bursky Center for Human Immunology and Immunotherapy Program, Washington University School of Medicine, Saint Louis, MO, USA.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2020 Dec 09; Vol. 6 (50). Date of Electronic Publication: 2020 Dec 09 (Print Publication: 2020).
DOI:	10.1126/sciadv.abe3024
Abstrakt:	We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited largely equivalent lymphocyte counts, fewer monocytes, and lower surface human leukocyte antigen (HLA)-class II expression on selected monocyte populations. Furthermore, decreased HLA-DR on intermediate monocytes predicted severe COVID-19 disease. In contrast to prevailing assumptions, very few (7 of 168) patients with COVID-19 exhibited cytokine profiles indicative of cytokine storm syndrome. After controlling for multiple factors including age and sample time point, patients with COVID-19 exhibited lower cytokine levels than patients with influenza. Up-regulation of IL-6, G-CSF, IL-1RA, and MCP1 predicted death in patients with COVID-19 but were not statistically higher than patients with influenza. Single-cell transcriptional profiling revealed profound suppression of interferon signaling among patients with COVID-19. When considered across the spectrum of peripheral immune profiles, patients with COVID-19 are less inflamed than patients with influenza. (Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).)
Databáze:	MEDLINE
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