NK cell infiltration is associated with improved overall survival in solid cancers: A systematic review and meta-analysis.

Autor:	Nersesian S; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Schwartz SL; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Grantham SR; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., MacLean LK; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Lee SN; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Pugh-Toole M; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Boudreau JE; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada; Department of Pathology, Dalhousie University, Halifax, NS, Canada. Electronic address: Jeanette.boudreau@dal.ca.
Jazyk:	angličtina
Zdroj:	Translational oncology [Transl Oncol] 2021 Jan; Vol. 14 (1), pp. 100930. Date of Electronic Publication: 2020 Nov 10.
DOI:	10.1016/j.tranon.2020.100930
Abstrakt:	The immune landscape of a tumor is highly connected to patient prognosis and response to treatment, but little is known about how natural killer (NK) cells predict overall survival (OS) among patients with solid tumors. We present the first meta-analysis on NK cell infiltration into solid tumors as a prognostic indicator for OS, considering cancer types independently, and together. Samples were collected from 1973 to 2016 with results published between 1989 and 2020. From 53 studies, we found that NK cell infiltration corresponds with decreased risk of death (HR=0.34, 95% CI: 0.26-0.46; p<0.0001). Among studies that investigated the prognostic potential of NK cells in specific regions of the tumor, intraepithelial infiltration was better predictive of OS than NK infiltration in the tumor-adjacent stroma. Generally, NK cell infiltration is lower in advanced-stage and lower-grade tumors; nevertheless, it remains prognostically beneficial. This meta-analysis highlights an important prognostic role of NK cells in solid tumors, but exposes that few studies have considered the contributions of NK cells. Toward NK cell-based immunotherapies, it will be important to understand the conditions under which NK cells can be effective agents of tumor control. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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