Aberrant immunophenotypes in acute lymphoblastic leukemia.
| Autor: | Cuéllar-Mendoza ME; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico., Chávez-Sánchez FR; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico., Dorantes-Acosta E; Departamento de Hemato-Oncología, Hospital Infantil de México Federico Gómez, Mexico., Arsuaga-Jiménez BM; Departamento de Oncología, Instituto Nacional de Pediatría. Mexico City, Mexico., Zapata-Tarrés M; Departamento de Oncología, Instituto Nacional de Pediatría. Mexico City, Mexico. |
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| Jazyk: | angličtina |
| Zdroj: | Boletin medico del Hospital Infantil de Mexico [Bol Med Hosp Infant Mex] 2020; Vol. 77 (6), pp. 287-292. |
| DOI: | 10.24875/BMHIM.20000171 |
| Abstrakt: | Acute lymphoblastic leukemia (ALL) is the most prevalent hematologic neoplasia worldwide. To classify leukemia, we analyzed the immunophenotypic characteristics in the neoplastic cells obtained with antibodies by cell flow cytometry or immunohistochemistry. The aberrant immunophenotypes are antigen expression patterns that differ from the normal hematopoietic maturation process, which can include some different lineage antigens such as myeloid antigens in ALL or asynchronous expression of antigens. These aberrant immunophenotypes have been studied as prognostic factors and residual disease markers. In this review, some aspects of aberrant immunophenotypes are addressed, including definition, epidemiology, and potential uses. (Copyright: © 2020 Permanyer.) |
| Databáze: | MEDLINE |
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