Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis.

Autor:	Hamilton OKL; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Dementia Research Institute, University of Edinburgh, Edinburgh, UK.; Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK., Backhouse EV; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Janssen E; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Jochems ACC; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Maher C; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Ritakari TE; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Stevenson AJ; Dementia Research Institute, University of Edinburgh, Edinburgh, UK.; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Xia L; Department of Psychology, University of Edinburgh, Edinburgh, UK., Deary IJ; Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Wardlaw JM; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Dementia Research Institute, University of Edinburgh, Edinburgh, UK.; Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2021 Apr; Vol. 17 (4), pp. 665-685. Date of Electronic Publication: 2020 Nov 13.
DOI:	10.1002/alz.12221
Abstrakt:	This paper is a proposal for an update on the characterization of cognitive impairments associated with sporadic cerebral small vessel disease (SVD). We pose a series of questions about the nature of SVD-related cognitive impairments and provide answers based on a comprehensive review and meta-analysis of published data from 69 studies. Although SVD is thought primarily to affect executive function and processing speed, we hypothesize that SVD affects all major domains of cognitive ability. We also identify low levels of education as a potentially modifiable risk factor for SVD-related cognitive impairment. Therefore, we propose the use of comprehensive cognitive assessments and the measurement of educational level both in clinics and research settings, and suggest several recommendations for future research. (© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze:	MEDLINE
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