Autophagy Activation by Resveratrol Reduces Severity of Experimental Rheumatoid Arthritis.

Autor: Fernández-Rodríguez JA; Grupo de Investigación en Envejecimiento e Inflamación, SERGAS, Complexo Hospitalario Universitario A Coruña (CHUAC), Instituto de Investigación Biomédica A Coruña (INIBIC), Agrupación Estratégica CICA-INIBIC, As Xubias 84, A Coruña, 15006, Spain., Almonte-Becerril M; Grupo de Investigación en Envejecimiento e Inflamación, SERGAS, Complexo Hospitalario Universitario A Coruña (CHUAC), Instituto de Investigación Biomédica A Coruña (INIBIC), Agrupación Estratégica CICA-INIBIC, As Xubias 84, A Coruña, 15006, Spain.; Universidad Intercultural Estado de Puebla, Calle Principal a Lipuntahuaca S/N, Lipuntahuaca, Puebla, 73475, México., Ramil-Gómez O; Grupo de Investigación en Envejecimiento e Inflamación, SERGAS, Complexo Hospitalario Universitario A Coruña (CHUAC), Instituto de Investigación Biomédica A Coruña (INIBIC), Agrupación Estratégica CICA-INIBIC, As Xubias 84, A Coruña, 15006, Spain., Hermida-Carballo L; Grupo de Investigación en Envejecimiento e Inflamación, SERGAS, Complexo Hospitalario Universitario A Coruña (CHUAC), Instituto de Investigación Biomédica A Coruña (INIBIC), Agrupación Estratégica CICA-INIBIC, As Xubias 84, A Coruña, 15006, Spain., Viñas-Diz S; Grupo de Investigación en Envejecimiento e Inflamación, SERGAS, Complexo Hospitalario Universitario A Coruña (CHUAC), Instituto de Investigación Biomédica A Coruña (INIBIC), Agrupación Estratégica CICA-INIBIC, As Xubias 84, A Coruña, 15006, Spain.; Departamento de Ciencias Biomédicas, Medicina y Fisioterapia, Universidade da Coruña (UDC), Campus de Oza, A Coruña, 15006, Spain., Vela-Anero Á; Grupo de Terapia Celular e Medicina Regenerativa, UDC, Campus de Oza, A Coruña, 15006, Spain., Concha Á; Servicio de Patología, INIBIC, SERGAS, As Xubias 84, A Coruña, 15006, Spain., Camacho-Encina M; Grupo de Investigación en Reumatología, Agrupación Estratégica CICA-INIBIC, SERGAS, As Xubias, 84, A Coruña, 15006, Spain., Blanco FJ; Grupo de Investigación en Reumatología, Agrupación Estratégica CICA-INIBIC, SERGAS, As Xubias, 84, A Coruña, 15006, Spain., López-Armada MJ; Grupo de Investigación en Envejecimiento e Inflamación, SERGAS, Complexo Hospitalario Universitario A Coruña (CHUAC), Instituto de Investigación Biomédica A Coruña (INIBIC), Agrupación Estratégica CICA-INIBIC, As Xubias 84, A Coruña, 15006, Spain.
Jazyk: angličtina
Zdroj: Molecular nutrition & food research [Mol Nutr Food Res] 2021 Jan; Vol. 65 (2), pp. e2000377. Date of Electronic Publication: 2020 Dec 07.
DOI: 10.1002/mnfr.202000377
Abstrakt: Scope: Previous work reported that dietary supplementation with resveratrol lowers synovial hyperplasia, inflammatory and oxidative damage in an antigen-induced arthritis (AIA) model. Here, it is investigated whether resveratrol can regulate the abnormal synovial proliferation by inducing autophagy and controlling the associated inflammatory response.
Methods and Results: Animals treated with resveratrol 8 weeks before AIA induction show the highest significant signal for microtubule-associated protein 1 light chain 3 by confocal microscopy. Besides, resveratrol significantly reduces p62 expression, but it does not increase the signal of beclin-1. Also, active caspase-3 expression, as well as poly(ADP-ribose) polymerase, is upregulated in the AIA group, and is significantly reduced in resveratrol-treated AIA group. Resveratrol also mitigates angiopoietin-1 and vascular endothelial growth factor signals. Finally, resveratrol significantly reduces the serum levels of IL-1β, C reactive protein, and prostaglandin E2, as well as nuclear factor κB synovial tissue expression, which shows a significant correlation with p62 expression.
Conclusion: Dietary supplementation with resveratrol induces the noncanonical autophagy pathway and limits the cross-talk with inflammation, which in consequence modulates the synovial hyperplasia. Preventive strategies that incorporate dietary intervention with resveratrol may offer a potential therapeutic alternative to drugs to influence the risk of rheumatoid arthritis and influence its course.
(© 2020 Wiley-VCH GmbH.)
Databáze: MEDLINE
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