Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition.

Autor: Kinatukara P; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India., Subramaniyan PS; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Patil GS; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Shambhavi S; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Singh S; Department of Biology, Indian Institute of Science Education and Research, Pune, Maharashtra, 411008, India., Mhetre A; Department of Biology, Indian Institute of Science Education and Research, Pune, Maharashtra, 411008, India., Madduri MK; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India., Soundararajan A; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India., Patel KD; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India., Shekar PC; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Kamat SS; Department of Biology, Indian Institute of Science Education and Research, Pune, Maharashtra, 411008, India., Kumar S; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India. satishk.scientist@gmail.com.; Department of Biotechnology, School of Interdisciplinary and Applied Sciences, Central University of Haryana, Jant-Pali, Mahendergarh, Haryana, 123029, India. satishk.scientist@gmail.com., Sankaranarayanan R; CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India. sankar@ccmb.res.in.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. sankar@ccmb.res.in.
Jazyk: angličtina
Zdroj: Transgenic research [Transgenic Res] 2020 Dec; Vol. 29 (5-6), pp. 553-562. Date of Electronic Publication: 2020 Nov 13.
DOI: 10.1007/s11248-020-00219-6
Abstrakt: Disco-interacting protein 2 is a highly conserved three-domain protein with two tandem Adenylate-forming domains. It is proposed to influence the processes involved in neuronal development by influencing lipid metabolism and remains to be characterized. In this study, we show that Disco-interacting protein 2a null mice do not exhibit overt phenotype defects. However, the body composition differences were observed in these mice under different dietary regimens. The neutral lipid composition of two different diets was characterized, and it was observed that the new-born mice grow relatively slower than the wild-type mice with delayed appearance of features such as dentition when fed with high-triacylglycerol NIN-formulation diet. The high-diacylglycerol Safe-formulation diet was found to accumulate more fat mass in mice than those fed with high-triacylglycerol NIN-formulation diet beyond 10 months. These findings point to a proposed relationship between dietary components (particularly the lipid composition) and body composition along with the growth of neonates in mice lacking the gene Disco-interacting protein 2a.
Databáze: MEDLINE
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