A thalamocortical top-down circuit for associative memory.

Autor: Pardi MB; Max Planck Institute for Brain Research, 60438 Frankfurt, Germany., Vogenstahl J; Max Planck Institute for Brain Research, 60438 Frankfurt, Germany., Dalmay T; Max Planck Institute for Brain Research, 60438 Frankfurt, Germany.; Donders Centre for Neuroscience, Faculty of Science, Radboud University, 6525 AJ Nijmegen, Netherlands., Spanò T; Max Planck Institute for Brain Research, 60438 Frankfurt, Germany.; Faculty of Biological Sciences, Goethe Universität Frankfurt, 60438 Frankfurt, Germany., Pu DL; Max Planck Institute for Brain Research, 60438 Frankfurt, Germany., Naumann LB; Bernstein Center for Computational Neuroscience Berlin, 10115 Berlin, Germany.; Department of Electrical Engineering and Computer Science, Technische Universität Berlin, 10587 Berlin, Germany., Kretschmer F; Max Planck Institute for Brain Research, 60438 Frankfurt, Germany., Sprekeler H; Bernstein Center for Computational Neuroscience Berlin, 10115 Berlin, Germany.; Department of Electrical Engineering and Computer Science, Technische Universität Berlin, 10587 Berlin, Germany., Letzkus JJ; Max Planck Institute for Brain Research, 60438 Frankfurt, Germany. johannes.letzkus@brain.mpg.de.; Institute for Physiology I, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2020 Nov 13; Vol. 370 (6518), pp. 844-848.
DOI: 10.1126/science.abc2399
Abstrakt: The sensory neocortex is a critical substrate for memory. Despite its strong connection with the thalamus, the role of direct thalamocortical communication in memory remains elusive. We performed chronic in vivo two-photon calcium imaging of thalamic synapses in mouse auditory cortex layer 1, a major locus of cortical associations. Combined with optogenetics, viral tracing, whole-cell recording, and computational modeling, we find that the higher-order thalamus is required for associative learning and transmits memory-related information that closely correlates with acquired behavioral relevance. In turn, these signals are tightly and dynamically controlled by local presynaptic inhibition. Our results not only identify the higher-order thalamus as a highly plastic source of cortical top-down information but also reveal a level of computational flexibility in layer 1 that goes far beyond hard-wired connectivity.
(Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
Databáze: MEDLINE
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