A Multidisciplinary Approach to Fungal Infections: One-Year Experiences of a Center of Expertise in Mycology.

Autor:	Janssen NAF; Center of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The Netherlands.; Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Brüggemann RJM; Center of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The Netherlands.; Department of Pharmacy, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Reijers MH; Center of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The Netherlands.; Department of Pulmonology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Henriet SSV; Center of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The Netherlands.; Department of Pediatric Infectious Diseases and Immunology, Radboudumc Amalia Children's Hospital, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Ten Oever J; Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., de Mast Q; Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Berk Y; Department of Pulmonary Diseases, Canisius-Wilhelmina Hospital (CWZ), 6532 SZ Nijmegen, The Netherlands., de Kort EA; Center of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The Netherlands.; Department of Hematology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Kullberg BJ; Center of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The Netherlands.; Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Netea MG; Center of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The Netherlands.; Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Buil JB; Center of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The Netherlands.; Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Rahamat-Langendoen JC; Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Bury D; Department of Pharmacy, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Muilwijk EW; Department of Pharmacy, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Meis JF; Center of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The Netherlands.; Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital (CWZ), 6532 SZ Nijmegen, The Netherlands., Verweij PE; Center of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The Netherlands.; Department of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., van de Veerdonk FL; Center of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The Netherlands.; Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Jazyk:	angličtina
Zdroj:	Journal of fungi (Basel, Switzerland) [J Fungi (Basel)] 2020 Nov 10; Vol. 6 (4). Date of Electronic Publication: 2020 Nov 10.
DOI:	10.3390/jof6040274
Abstrakt:	Invasive fungal diseases (IFDs) often represent complicated infections in complex patient populations. The Center of Expertise in Mycology Radboudumc/CWZ (EMRC) organizes a biweekly multidisciplinary mycology meeting to discuss patients with severe fungal infections and to provide comprehensive advice regarding diagnosis and treatment. Here, we describe the patient population discussed at these meetings during a one-year period with regards to their past medical history, diagnosis, microbiological and other diagnostic test results and antifungal therapy. The majority of patients discussed were adults (83.1%), 62.5% of whom suffered from pulmonary infections or signs/symptoms, 10.9% from otorhinolaryngeal infections and/or oesophagitis, 9.4% from systemic infections and 9.4% from central nervous system infections. Among children, 53.8% had pulmonary infections or signs/symptoms, 23.1% systemic fungal infections and 23.1% other, miscellaneous fungal infections. 52.5% of adult patients with pulmonary infections/symptoms fulfilled diagnostic criteria for chronic pulmonary aspergillosis (CPA). Culture or polymerase chain reaction (PCR) demonstrated fungal pathogens in 81.8% of patients, most commonly Aspergillus . A multidisciplinary mycology meeting can be a useful addition to the care for patients with (I)FDs and can potentially aid in identifying healthcare and research needs regarding the field of fungal infections. The majority of patients discussed at the multidisciplinary meetings suffered from pulmonary infections, predominantly CPA.
Databáze:	MEDLINE
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