Clinical Significance of Integrin Subunit Beta 4 in Head and Neck Squamous Cell Carcinoma.

Autor: Li GS; Department of Organic Chemistry and Medicinal Chemistry, Pharmaceutical College, Guangxi Medical University, Nanning, People's Republic of China., Hou W; Guangxi Key Laboratory of Thalassemia Research, Life Sciences Institute, Guangxi Medical University, Nanning, People's Republic of China., Chen G; Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China., Yao YX; Department of Organic Chemistry and Medicinal Chemistry, Pharmaceutical College, Guangxi Medical University, Nanning, People's Republic of China., Chen XY; Department of Organic Chemistry and Medicinal Chemistry, Pharmaceutical College, Guangxi Medical University, Nanning, People's Republic of China., Zhang XG; Department of Organic Chemistry and Medicinal Chemistry, Pharmaceutical College, Guangxi Medical University, Nanning, People's Republic of China., Liang Y; Department of Organic Chemistry and Medicinal Chemistry, Pharmaceutical College, Guangxi Medical University, Nanning, People's Republic of China., Li MX; Department of Organic Chemistry and Medicinal Chemistry, Pharmaceutical College, Guangxi Medical University, Nanning, People's Republic of China., Huang ZG; Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China., Dang YW; Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China., Liang QH; Department of Clinical Laboratory, Guangxi Jiangbin Hospital, Nanning, People's Republic of China., Wu HY; Department of Cell Biology and Genetics, School of Pre-Clinical Medicine, Guangxi Medical University, Nanning, People's Republic of China., Li RQ; Department of Clinical Laboratory, Guangxi Jiangbin Hospital, Nanning, People's Republic of China., Wei HY; Department of Organic Chemistry and Medicinal Chemistry, Pharmaceutical College, Guangxi Medical University, Nanning, People's Republic of China.
Jazyk: angličtina
Zdroj: Cancer biotherapy & radiopharmaceuticals [Cancer Biother Radiopharm] 2022 May; Vol. 37 (4), pp. 256-275. Date of Electronic Publication: 2020 Nov 11.
DOI: 10.1089/cbr.2020.3943
Abstrakt: Background: The expression level and clinical significance of integrin subunit beta 4 ( ITGB4 ) in head and neck squamous cell carcinoma (HNSCC) remain unclear. Materials and Methods: Expression of ITGB4 in HNSCC tissues was evaluated by calculating standard mean differences (SMDs) based on gene chips, RNA-seq, and immunohistochemistry data ( n  = 2330) from multiple sources. Receiver operating characteristic (ROC) curves were used to detect the ability of ITGB4 to distinguish HNSCC from non-HNSCC samples. The relationship between the expression level of ITGB4 and clinical parameters was evaluated by calculating SMDs. Results: Identical results of mRNA and protein levels indicated remarkable up-expression of ITGB4 in HNSCC tissues. Further ROC curves showed that ITGB4 could distinguish HNSCC from non-HNSCC samples. Genetic alteration analysis of ITGB4 in HNSCC indicated that overexpression of ITGB4 in HNSCC was likely not owing to genetic alteration of ITGB4 . Moreover, ITGB4 overexpression level may be correlated with clinical T stage. Conclusion: ITGB4 likely plays an essential role in HNSCC occurrence based on our study and its potential diagnostic value is worthy of further exploration in the future.
Databáze: MEDLINE