Precision Therapy of Pancreatic Cancer: From Bench to Bedside.
| Autor: | Ciecielski KJ; Comprehensive Cancer Center Munich (CCCM), Klinikum rechts der Isar, Technische Universität München, Munich, Germany., Berninger A; Comprehensive Cancer Center Munich (CCCM), Klinikum rechts der Isar, Technische Universität München, Munich, Germany., Algül H; Comprehensive Cancer Center Munich (CCCM), Klinikum rechts der Isar, Technische Universität München, Munich, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Visceral medicine [Visc Med] 2020 Oct; Vol. 36 (5), pp. 373-380. Date of Electronic Publication: 2020 Oct 06. |
| DOI: | 10.1159/000509232 |
| Abstrakt: | Background: Pancreatic ductal adenocarcinoma (PDAC), with a mortality rate of 94% and a 5-year-survival rate of only 8%, is one of the deadliest cancer entities worldwide, and early diagnostic methods as well as effective therapies are urgently needed. Summary: This review summarizes current clinical procedure and recent developments of oncological therapy in the palliative setting of metastatic PDAC. It further gives examples of successful, as well as failed, targeted therapy approaches and finally discusses promising ongoing research into the decade-old question of the "undruggability" of KRAS. Key Messages: Bench-driven concepts change the clinical landscape from "one size fits all" towards precision medicine. With growing insight into the molecular mechanisms of pancreatic cancer the era of targeted therapy in PDAC is gaining a new momentum. Competing Interests: Katrin Jana Ciecielski, Alexandra Berninger, and Hana Algül declare they have no conflicts of interest directly relevant to the content of this article. (Copyright © 2020 by S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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