Seroprevalence of human alphaherpesvirus 1 and 2 among pregnant women infected or uninfected with Zika virus from Rio de Janeiro, Brazil.

Autor: Lima LRP; Laboratory of Molecular Virology Molecular, Oswaldo Cruz Institution, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil., Dos Santos Pereira JS; Department of Virology, Institution of Microbiology Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., de Almeida NAA; Laboratory of Molecular Virology Molecular, Oswaldo Cruz Institution, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil., de Meneses MDF; Department of Virology, Institution of Microbiology Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Aguiar SF; Central Laboratory of Public Heath Noel Nutels-LACEN-RJ, Rio de Janeiro, Brazil., Fernandes CAS; Central Laboratory of Public Heath Noel Nutels-LACEN-RJ, Rio de Janeiro, Brazil., Azevedo RC; Department of Virology, Institution of Microbiology Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., de Paula VS; Laboratory of Molecular Virology Molecular, Oswaldo Cruz Institution, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2021 Jun; Vol. 93 (6), pp. 3383-3388. Date of Electronic Publication: 2020 Nov 22.
DOI: 10.1002/jmv.26665
Abstrakt: Pregnant women are an important group to be monitored for infection due to the risk of transmitting infections to their babies. Both herpes simples virus (HSV) and Zika virus (ZIKV) are neurotropic viruses that can be transmitted congenitally. In this study, the prevalence and risk factors of HSV among Zika-positive and -negative pregnant women from Rio de Janeiro, Brazil, were evaluated and compared. About 167 serum samples included in our study were from pregnant women with ZIKV infection symptoms, who were attended to in different hospitals in Rio de Janeiro between November 2015 to February 2016. Blood samples collected from 167 pregnant women were used for this study. The presence of HSV antibodies and viremia were evaluated by commercial ELISA and quantitative real-time polymerase chain reaction analyses, respectively. The data obtained from medical records were statistically analyzed. The HSV-1 and HSV-2 prevalence among pregnant women was 80.2% and 12.5% for Zika-positive women and 84.5% and 5.6% for Zika-negative women, respectively. None of the pregnant women exhibited HSV viremia. Age, trimester of gestation, and skin color were associated with HSV-1 and HSV-2 prevalence among the groups studied. HSV-2 was more prevalent in Zika-positive pregnant women than in Zika-negative pregnant women, and this simultaneous infection should be better investigated in future studies.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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