Higher Increase in Plasma DHA in Females Compared to Males Following EPA Supplementation May Be Influenced by a Polymorphism in ELOVL2: An Exploratory Study.

Autor: Metherel AH; Department of Nutritional Sciences, University of Toronto, Toronto, ON, M5S 1A8, Canada., Irfan M; Department of Nutritional Sciences, University of Toronto, Toronto, ON, M5S 1A8, Canada., Klingel SL; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada., Mutch DM; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada., Bazinet RP; Department of Nutritional Sciences, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Jazyk: angličtina
Zdroj: Lipids [Lipids] 2021 Mar; Vol. 56 (2), pp. 211-228. Date of Electronic Publication: 2020 Nov 10.
DOI: 10.1002/lipd.12291
Abstrakt: Young adult females have higher blood docosahexaenoic acid (DHA), 22:6n-3 levels than males, and this is believed to be due to higher DHA synthesis rates, although DHA may also accumulate due to a longer half-life or a combination of both. However, sex differences in blood fatty acid responses to eicosapentaenoic acid (EPA), 20:5n-3 or DHA supplementation have not been fully investigated. In this exploratory analysis, females and males (n = 14-15 per group) were supplemented with 3 g/day EPA, 3 g/day DHA, or olive oil control for 12 weeks. Plasma was analyzed for sex effects at baseline and changes following 12 weeks' supplementation for fatty acid levels and carbon-13 signature (δ 13 C). Following EPA supplementation, the increase in plasma DHA in females (+23.8 ± 11.8, nmol/mL ± SEM) was higher than males (-13.8 ± 9.2, p < 0.01). The increase in plasma δ 13 C-DHA of females (+2.79 ± 0.31, milliUrey (mUr ± SEM) compared with males (+1.88 ± 0.44) did not reach statistical significance (p = 0.10). The sex effect appears driven largely by increased plasma DHA in the AA genotype of females (+58.8 ± 11.5, nmol/mL ± SEM, n = 5) compared to GA + GG in females (+4.34 ± 13.5, n = 9) and AA in males (-29.1 ± 17.2, n = 6) for rs953413 in the ELOVL2 gene (p < 0.001). In conclusion, EPA supplementation increases plasma DHA levels in females compared to males, which may be dependent on the AA genotype for rs953413 in ELOVL2.
(© 2020 AOCS.)
Databáze: MEDLINE
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