| Autor: |
Calissi G; Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM), Madrid, Spain., Lam EW; Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM), London, UK., Link W; Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM), Madrid, Spain. walink@iib.uam.es. |
| Jazyk: |
angličtina |
| Zdroj: |
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2021 Jan; Vol. 20 (1), pp. 21-38. Date of Electronic Publication: 2020 Nov 10. |
| DOI: |
10.1038/s41573-020-0088-2 |
| Abstrakt: |
FOXO proteins are transcription factors that are involved in numerous physiological processes and in various pathological conditions, including cardiovascular disease, cancer, diabetes and chronic neurological diseases. For example, FOXO proteins are context-dependent tumour suppressors that are frequently inactivated in human cancers, and FOXO3 is the second most replicated gene associated with extreme human longevity. Therefore, pharmacological manipulation of FOXO proteins is a promising approach to developing therapeutics for cancer and for healthy ageing. In this Review, we overview the role of FOXO proteins in health and disease and discuss the pharmacological approaches to modulate FOXO function. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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