Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans.

Autor: Oude Munnink BB; Department of Viroscience, Erasmus MC, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, Netherlands. b.oudemunnink@erasmusmc.nl., Sikkema RS; Department of Viroscience, Erasmus MC, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, Netherlands., Nieuwenhuijse DF; Department of Viroscience, Erasmus MC, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, Netherlands., Molenaar RJ; Royal GD, Deventer, Netherlands., Munger E; Department of Viroscience, Erasmus MC, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, Netherlands., Molenkamp R; Department of Viroscience, Erasmus MC, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, Netherlands., van der Spek A; Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, Netherlands., Tolsma P; Municipal Health Services GGD Brabant-Zuidoost, Eindhoven, Netherlands., Rietveld A; Municipal Health Services GGD Hart voor Brabant, 's-Hertogenbosch, Netherlands., Brouwer M; Municipal Health Services GGD Hart voor Brabant, 's-Hertogenbosch, Netherlands., Bouwmeester-Vincken N; Municipal Health Services GGD Limburg-Noord, Venlo, Netherlands., Harders F; Wageningen Bioveterinary Research, Lelystad, Netherlands., Hakze-van der Honing R; Wageningen Bioveterinary Research, Lelystad, Netherlands., Wegdam-Blans MCA; Stichting PAMM, Veldhoven, Netherlands., Bouwstra RJ; Royal GD, Deventer, Netherlands., GeurtsvanKessel C; Department of Viroscience, Erasmus MC, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, Netherlands., van der Eijk AA; Department of Viroscience, Erasmus MC, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, Netherlands., Velkers FC; Division of Farm Animal Health, Department of Population Health Sciences, Utrecht University, Utrecht, Netherlands., Smit LAM; Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands., Stegeman A; Division of Farm Animal Health, Department of Population Health Sciences, Utrecht University, Utrecht, Netherlands., van der Poel WHM; Wageningen Bioveterinary Research, Lelystad, Netherlands., Koopmans MPG; Department of Viroscience, Erasmus MC, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, Netherlands.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2021 Jan 08; Vol. 371 (6525), pp. 172-177. Date of Electronic Publication: 2020 Nov 10.
DOI: 10.1126/science.abe5901
Abstrakt: Animal experiments have shown that nonhuman primates, cats, ferrets, hamsters, rabbits, and bats can be infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In addition, SARS-CoV-2 RNA has been detected in felids, mink, and dogs in the field. Here, we describe an in-depth investigation using whole-genome sequencing of outbreaks on 16 mink farms and the humans living or working on these farms. We conclude that the virus was initially introduced by humans and has since evolved, most likely reflecting widespread circulation among mink in the beginning of the infection period, several weeks before detection. Despite enhanced biosecurity, early warning surveillance, and immediate culling of animals in affected farms, transmission occurred between mink farms in three large transmission clusters with unknown modes of transmission. Of the tested mink farm residents, employees, and/or individuals with whom they had been in contact, 68% had evidence of SARS-CoV-2 infection. Individuals for which whole genomes were available were shown to have been infected with strains with an animal sequence signature, providing evidence of animal-to-human transmission of SARS-CoV-2 within mink farms.
(Copyright © 2021, American Association for the Advancement of Science.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje