| Autor: |
El-Hussieny M; Pathology, Minia University Faculty of Medicine, El Minia, Egypt., Mohammed EM; Obstetrics and Gynecology, Minia University Faculty of Medicine, El Minia, Egypt., Zenhom NM; Biochemistry, Minia University Faculty of Medicine, El Minia, Egypt., Refaie MM; Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt., Okasha AM; Biochemistry, Minia University Faculty of Medicine, El Minia, Egypt., Tawab MAE; Pathology, Minia University Faculty of Medicine, El Minia, Egypt. |
| Jazyk: |
angličtina |
| Zdroj: |
Fetal and pediatric pathology [Fetal Pediatr Pathol] 2021 Jun; Vol. 40 (3), pp. 222-232. Date of Electronic Publication: 2020 Nov 11. |
| DOI: |
10.1080/15513815.2020.1843574 |
| Abstrakt: |
Objectives: Placenta accreta (PA) can be life-threatening due to postpartum hemorrhage and may lead to cesarean hysterectomy. We investigated the expression of Matrix metalloproteinase-2 (MMP-2), β-catenin, E-cadherin (E-CAD), transforming growth factor β1 (TGF-β1), glutathione peroxidase 1 (GPx-1), reduced glutathione (GSH) and superoxide dismutase (SOD) in PA compared to controls to determine if alterations may contribute to PA. Materials and methods: Twenty six PA and 31 controls were evaluated immunohistochemically for expression of MMP-2, β-catenin and E-CAD on villous and extravillous trophoblasts. TGF-β1 and GPx-1 mRNA levels were evaluated by rt-PCR. We measured biochemical levels of GSH and SOD. Results: Significant increases of MMP-2 immunoexpression, GPx-1 mRNA, SOD and GSH levels, decreases in immunoexpression of E-CAD and β-catenin and TGF-β1 mRNA were found in PA. Conclusion: These findings suggest that loss of cell-cell adhesion and increased antioxidants level may have a role in PA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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