| Autor: |
Anton C; Department of Gastroenterology, Faculty of Medicine, 'Gr. T. Popa' University of Medicine and Pharmacy, 6th University Street, 700490 Iasi, Romania., Ciobica A; Department of Biology, Faculty of Biology, 'Alexandru Ioan Cuza' University of Iasi, Carol I Avenue, 20A, 700490 Iasi, Romania.; Department Center of Biomedical Research, Romanian Academy, Iasi Branch, Nr. 8, Carol I Avenue, No. 8, 700490 Iasi, Romania.; Department of Biology, Academy of Romanian Scientists, Splaiul Independentei Nr. 54, Sector 5, 050094 Bucuresti, Romania., Doroftei B; Department of Obstetrics and Gynecology, Faculty of Medicine, 'Gr. T. Popa' University of Medicine and Pharmacy, 6th University Street, 700490 Iasi, Romania., Maftei R; Clinical Department, Origyn Fertility Center, Palace Street, No 3C, 700032 Iasi, Romania., Ilea C; Department of Obstetrics and Gynecology, Faculty of Medicine, 'Gr. T. Popa' University of Medicine and Pharmacy, 6th University Street, 700490 Iasi, Romania., Darii Plopa N; Department of of Obstetrics and Gynecology, Grand Hôpital De Charleroi, Avenue du Centenaries 73, 6061 Charleroi, Belgium., Bolota M; Department of Obstetrics and Gynecology, Spitalul Clinic de Obstetrică și Ginecologie Cuza Vodă, 700032 Iasi, Romania., Anton E; Department of Obstetrics and Gynecology, Faculty of Medicine, 'Gr. T. Popa' University of Medicine and Pharmacy, 6th University Street, 700490 Iasi, Romania. |
| Abstrakt: |
Irritable bowel syndrome (IBS) is a gastrointestinal disease that negatively affects up to 20% of the population. Infertility is defined as a disorder of the reproductive system described by lack of success in achieving pregnancy after more than a year of regular unprotected sexual intercourse. The main purpose of our review was to analyze the available literature regarding the IBS-infertility connection. Another secondary purpose of the present paper was to find out if oxidative stress may be the missing puzzle that may explain this possible correlation. After analyzing the available literature we concluded that oxidative stress is a plausible mediator of the connection between both female and male fertility and IBS. However, the data lacks in direct evidence to confirm this hypothesis. Nevertheless, it is recommended that certain levels of oxidative stress should not be exceeded in order to decrease IBS symptoms and increase the odds of conception given that generation of reactive oxygen species (ROS) is an aftermath of metabolically active cells. Therefore, reducing the oxidative stress by living a healthier lifestyle with a balanced diet, rich in micronutrients, limited in caffeine and alcohol, avoiding smoking and maintaining a normal body mass index with regular physical exercise may promote fertility and help diminishing IBS symptomatology. Studies with measurements of biological samples are needed in order to assess the complex relationship between oxidative stress, IBS and infertility. |
