Bioactivity of abobotulinum toxin is preserved till 2 weeks upon storage at room temperature: Half body comparative study on rabbit model.
| Autor: | Esme P; Department of Dermatology and Venereology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey., Botsali A; Department of Dermatology and Venereology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey., Erbil H; Private Clinic, Ankara, Turkey., Aksoy OA; Department of Animal Experiments and Research Centre, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey., Caliskan E; Department of Dermatology and Venereology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of cosmetic dermatology [J Cosmet Dermatol] 2021 May; Vol. 20 (5), pp. 1367-1373. Date of Electronic Publication: 2020 Nov 25. |
| DOI: | 10.1111/jocd.13836 |
| Abstrakt: | Background: Breakages of the cold chain of botulinum neurotoxin A (BONT-A) preparations is not a rare event and occurs due to several unexpected and unintentional reasons during daily practice and intervention schedules could not be proposed due to the lack of data. Objective: To investigate the heat stability of abobotulinum toxin A (AboBONT-A) in terms of efficacy and duration of action upon storage at room temperature (25°C) for 2, 4, and 8 weeks. Methods and Materials: Twenty rabbits were divided into four groups and received an injection of ideally stored AboBONT-A (Group 1) and stored AboBONT-A for 2 (Group 2), 4 (Group 3), and 8 weeks (Group 4) at room temperature into the anterior auricular muscle. All rabbits were followed up and photographed by weekly for 16 weeks. Grade of paralysis was evaluated by using a modified visual scoring system. Results: No significant alteration was found in initial potency of stored AboBONT-A at room temperature for up to 4 weeks. Storage at room temperature for 2 weeks did not affect the duration of action (group 2; P = .69), and faster recovery was observed in group 3 and group 4. Conclusion: The bioactivity of AboBONT-A is not altered till 2 weeks upon storage at room temperature. (© 2020 Wiley Periodicals LLC.) |
| Databáze: | MEDLINE |
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