A new phytocosmetic preparation from Thymus vulgaris stimulates adipogenesis and controls skin aging process: In vitro studies and topical effects in a double-blind placebo-controlled clinical trial.

Autor: Caverzan J; Research and Development Department, Chemyunion Química Ltda, Sorocaba, Brazil., Mussi L; Research and Development Department, Chemyunion Química Ltda, Sorocaba, Brazil., Sufi B; Research and Development Department, Chemyunion Química Ltda, Sorocaba, Brazil., Padovani G; Research and Development Department, Chemyunion Química Ltda, Sorocaba, Brazil., Nazato L; Research and Development Department, Chemyunion Química Ltda, Sorocaba, Brazil., Camargo FB Junior; Research and Development Department, Chemyunion Química Ltda, Sorocaba, Brazil., Magalhães WV; Research and Development Department, Chemyunion Química Ltda, Sorocaba, Brazil., Di Stasi LC; Laboratory of Phytomedicines, Pharmacology and Biotechnology (PhytoPharmaTech), Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University (Unesp), Botucatu, Brazil.
Jazyk: angličtina
Zdroj: Journal of cosmetic dermatology [J Cosmet Dermatol] 2021 Jul; Vol. 20 (7), pp. 2190-2202. Date of Electronic Publication: 2020 Nov 10.
DOI: 10.1111/jocd.13818
Abstrakt: Background: The use of the injectable products for soft tissue augmentation and treatment of skin aging is an uncomfortable, invasive and related to several complications, and chronic reactions, mainly after long-term application. Efforts to develop new topically active anti-aging products with fewer adverse effects are a huge challenge that should be faced.
Aims: We evaluated the anti-aging effects of a phytocosmetic preparation containing Thymus vulgaris associated with lecithin (ThymLec) on the facial wrinkles, expression lines, and face oval remodeling using a double-blind placebo-controlled clinical trial and in vitro cell culture assays.
Methods: A clinical trial was conducted to evaluate the effects of ThymLec 2% on the area, length, and depth of the perioral and crow's feet wrinkles, nasolabial and smile lines, as well as face oval remodeling in female volunteers using a sophisticated Bio3D Structured-light Scanner. In the in vitro studies using 3T3-L1 mouse embryonic fibroblasts, adiponectin was measured by immunoenzymatic assay, adipogenesis by the AdipoRed reagent method, and the PPAR-γ expression by RT-PCR analysis.
Results: Topical treatment with ThymLec 2% reduced facial wrinkles and expression lines promoting a face oval remodeling. In the in vitro studies, ThymLec upregulated the PPAR-γ expression increasing adiponectin production and stimulating the adipogenesis process.
Conclusions: The phytocosmetic preparation containing Thymus vulgaris and lecithin is an innovative and safe topical anti-aging product promoting fat tissue augmentation by adipogenesis stimulation via the upregulation of PPAR-γ expression and adiponectin production.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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