Recent advances in 3D bioprinting of musculoskeletal tissues.

Autor:	Potyondy T; Center for Minimally Invasive Therapeutics (C-MIT), Los Angeles, CA, United States of America.; Department of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, CA, United States of America.; Authors contributed equally to the work., Uquillas JA; Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven 5600 MB, The Netherlands., Tebon PJ; Center for Minimally Invasive Therapeutics (C-MIT), Los Angeles, CA, United States of America.; Department of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, CA, United States of America., Byambaa B; Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital Harvard Medical School, Cambridge, MA, United States of America.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States of America., Hasan A; Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha, Qatar.; Biomedical Research Center, Qatar University, Doha, Qatar., Tavafoghi M; Center for Minimally Invasive Therapeutics (C-MIT), Los Angeles, CA, United States of America.; Department of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, CA, United States of America., Mary H; Center for Minimally Invasive Therapeutics (C-MIT), Los Angeles, CA, United States of America.; UFR Odontologie, Université de Reims-Champagne Ardennes, Reims, France., Aninwene GE 2nd; Center for Minimally Invasive Therapeutics (C-MIT), Los Angeles, CA, United States of America.; Department of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, CA, United States of America.; California NanoSystems Institute (CNSI), University of California-Los Angeles, Los Angeles, CA, United States of America., Pountos I; Academic Department of Trauma and Orthopaedics, University of Leeds, Leeds, United Kingdom.; Chapel Allerton Hospital, Leeds Teaching Hospitals, Leeds, United Kingdom., Khademhosseini A; Center for Minimally Invasive Therapeutics (C-MIT), Los Angeles, CA, United States of America.; Department of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, CA, United States of America.; Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, United States of America.; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, United States of America.; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, United States of America., Ashammakhi N; Center for Minimally Invasive Therapeutics (C-MIT), Los Angeles, CA, United States of America.; Department of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, CA, United States of America.; Authors contributed equally to the work.; Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, United States of America.; Department of Biomedical Engineering, Michigan State University, East Lansing, MI, United States of America.
Jazyk:	angličtina
Zdroj:	Biofabrication [Biofabrication] 2021 Mar 10; Vol. 13 (2). Date of Electronic Publication: 2021 Mar 10.
DOI:	10.1088/1758-5090/abc8de
Abstrakt:	The musculoskeletal system is essential for maintaining posture, protecting organs, facilitating locomotion, and regulating various cellular and metabolic functions. Injury to this system due to trauma or wear is common, and severe damage may require surgery to restore function and prevent further harm. Autografts are the current gold standard for the replacement of lost or damaged tissues. However, these grafts are constrained by limited supply and donor site morbidity. Allografts, xenografts, and alloplastic materials represent viable alternatives, but each of these methods also has its own problems and limitations. Technological advances in three-dimensional (3D) printing and its biomedical adaptation, 3D bioprinting, have the potential to provide viable, autologous tissue-like constructs that can be used to repair musculoskeletal defects. Though bioprinting is currently unable to develop mature, implantable tissues, it can pattern cells in 3D constructs with features facilitating maturation and vascularization. Further advances in the field may enable the manufacture of constructs that can mimic native tissues in complexity, spatial heterogeneity, and ultimately, clinical utility. This review studies the use of 3D bioprinting for engineering bone, cartilage, muscle, tendon, ligament, and their interface tissues. Additionally, the current limitations and challenges in the field are discussed and the prospects for future progress are highlighted. (© 2021 IOP Publishing Ltd.)
Databáze:	MEDLINE
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