Aryl variation and anion effect on CT-DNA binding and in vitro biological studies of pyridinyl Ag(I) complexes.

Autor: Adeleke AA; School of Chemistry and Physics, University of Kwazulu-Natal, Pietermaritzburg Campus, Private Bag X01, Scottsville 3209, South Africa., Islam MS; Discipline of Biochemistry, School of Life Sciences, University of Kwazulu-Natal, Westville Campus, Private Bag X54001, Durban 4000, South Africa., Sanni O; Discipline of Biochemistry, School of Life Sciences, University of Kwazulu-Natal, Westville Campus, Private Bag X54001, Durban 4000, South Africa., Mocktar C; Discipline of Pharmaceutical Sciences, School of Health Sciences, University of Kwazulu-Natal, Westville Campus, Private Bag X54001, Durban 4000, South Africa., Zamisa SJ; School of Chemistry and Physics, University of Kwazulu-Natal, Westville Campus, Private Bag X54001, Westville 4001, South Africa., Omondi B; School of Chemistry and Physics, University of Kwazulu-Natal, Pietermaritzburg Campus, Private Bag X01, Scottsville 3209, South Africa. Electronic address: owaga@ukzn.ac.za.
Jazyk: angličtina
Zdroj: Journal of inorganic biochemistry [J Inorg Biochem] 2021 Jan; Vol. 214, pp. 111266. Date of Electronic Publication: 2020 Oct 05.
DOI: 10.1016/j.jinorgbio.2020.111266
Abstrakt: Synthesis and spectroscopic characterization of five ligands ((E)-2-((pyridin-2-ylmethylene)amino)phenol L1, 2-(pyridin-2-yl)benzo[d]thiazole L2, (E)-N-(2-fluorophenyl)-1-(pyridin-2-yl)methanimine L3, (E)-1-(pyridin-2-yl)-N-(p-tolyl)methanimine L4 and (E)-1-(pyridin-2-yl)-N-(thiophen-2-ylmethyl)methanimine L5 along with fifteen silver(I) complexes of L1 - L5, with a general formula [AgL 2 ] + X - (L = Schiff base and X = NO 3 - , ClO 4 - or CF 3 SO 3 - ) is reported. The structures of complexes [Ag(L4) 2 ]NO 3 , [Ag(L5) 2 ]NO 3 , [Ag(L3) 2 ]ClO 4 , [Ag(L4) 2 ]ClO 4 and [Ag(L5) 2 ]CF 3 SO 3 were determined unequivocally by single crystal X-ray diffraction analysis. Calf-thymus deoxyribonucleic acid (CT-DNA), bovine serum albumin (BSA) binding studies, antioxidant, and antibacterial studies were performed for all complexes. Complexes [Ag(L2) 2 ]NO 3 , [Ag(L5) 2 ]NO 3 , [Ag(L1) 2 ]ClO 4 and [Ag(L3) 2 ]ClO 4 whose ligands have an OH - and F - as substituents or with a thiophene or thiazole moiety showed better antibacterial activities with lower minimum inhibitory concentration (MIC) values compared to the standard ciprofloxacin, against most of the bacterial strains tested. Similarly, complexes [Ag(L1) 2 ]NO 3, [Ag(L2) 2 ]NO 3, [Ag(L3) 2 ]NO 3 and [Ag(L5) 2 ]NO 3 with the NO 3 - anion, [Ag(L1) 2 ]ClO 4 and [Ag(L2) 2 ]ClO 4 with ClO 4 - anion, and [Ag(L5) 2 ]CF 3 SO 3 with CF 3 SO 3 - anion showed higher activities for antioxidant studies. Complexes [Ag(L4) 2 ]ClO 4 and [Ag(L4) 2 ]CF 3 SO 3 with the Methyl substituent and CF 3 SO 3 - as the anion, displayed high antioxidant activities in FRAP (ferric reducing antioxidant power) than the standard ascorbic acid. Spectroscopic studies of all the complexes revealed their moderate to high interaction with calf thymus DNA via an intercalation mode. In addition, the relatively moderate interaction of most of the complexes with BSA was through a static quenching mechanism.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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