| Autor: |
Dharmadana D; School of Health and Biomedical Sciences, Translational Immunology and Nanotechnology (TIN) Program, RMIT University, Bundoora VIC3083, Australia. celine.valery@rmit.edu.au., Adamcik J, Ryan TM, Appiah Danso S, Chong CJH, Conn CE, Reynolds NP, Mezzenga R, Valéry C |
| Jazyk: |
angličtina |
| Zdroj: |
Nanoscale [Nanoscale] 2020 Nov 19; Vol. 12 (44), pp. 22680-22687. |
| DOI: |
10.1039/d0nr05622g |
| Abstrakt: |
Substance P neuropeptide is here reported to self-assemble into well-defined semi-flexible nanotubes. Using a blend of synchrotron small angle X-ray scattering, atomic force microscopy and other biophysical techniques, the natural peptide is shown to self-assemble into monodisperse 6 nm wide nanotubes, which can closely associate into nano-arrays with nematic properties. Using simple protocols, the nanotubes could be precipitated or mineralised while conserving their dimensions and core-shell morphology. Our discovery expands the small number of available monodisperse peptide nanotube systems for nanotechnology, beyond direct relevance to biologically functional peptide nanostructures since the substance P nanotubes are fundamentally different from typical amyloid fibrils. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
