Revised Framingham Stroke Risk Profile: Association with Cognitive Status and MRI-Derived Volumetric Measures.

Autor:	Pelcher I; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA., Puzo C; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA., Tripodis Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Aparicio HJ; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; VA Boston Healthcare System, U.S. Department of Veteran Affairs, Boston, MA, USA.; Framingham Heart Study, National Heart, Lung, and Blood, Framingham, MA, USA., Steinberg EG; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA., Phelps A; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA., Martin B; Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, MA, USA., Palmisano JN; Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, MA, USA., Vassey E; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA., Lindbergh C; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., McKee AC; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; VA Boston Healthcare System, U.S. Department of Veteran Affairs, Boston, MA, USA.; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.; Department of Veterans Affairs Medical Center, Bedford, MA, USA., Stein TD; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA.; VA Boston Healthcare System, U.S. Department of Veteran Affairs, Boston, MA, USA.; Framingham Heart Study, National Heart, Lung, and Blood, Framingham, MA, USA.; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.; Department of Veterans Affairs Medical Center, Bedford, MA, USA., Killiany RJ; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA.; Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA, USA., Au R; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Framingham Heart Study, National Heart, Lung, and Blood, Framingham, MA, USA.; Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA., Kowall NW; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; VA Boston Healthcare System, U.S. Department of Veteran Affairs, Boston, MA, USA., Stern RA; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA, USA.; Department of Neurosurgery, Boston University School of Medicine, Boston, MA, USA., Mez J; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Alosco ML; Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
Jazyk:	angličtina
Zdroj:	Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2020; Vol. 78 (4), pp. 1393-1408.
DOI:	10.3233/JAD-200803
Abstrakt:	Background: The Framingham Stroke Risk Profile (FSRP) was created in 1991 to estimate 10-year risk of stroke. It was revised in 2017 (rFSRP) to reflect the modern data on vascular risk factors and stroke risk. Objective: This study examined the association between the rFSRP and cognitive and brain aging outcomes among participants from the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS). Methods: Cross-sectional rFSRP was computed at baseline for 19,309 participants (mean age = 72.84, SD = 8.48) from the NACC-UDS [9,697 (50.2%) normal cognition, 4,705 (24.4%) MCI, 4,907 (25.4%) dementia]. Multivariable linear, logistic, or ordinal regressions examined the association between the rFSRP and diagnostic status, neuropsychological test performance, CDR® Sum of Boxes, as well as total brain volume (TBV), hippocampal volume (HCV), and log-transformed white matter hyperintensities (WMH) for an MRI subset (n = 1,196). Models controlled for age, sex, education, racial identity, APOEɛ4 status, and estimated intracranial volume for MRI models. Results: The mean rFSRP probability was 10.42% (min = 0.50%, max = 95.71%). Higher rFSRP scores corresponded to greater CDR Sum of Boxes (β= 0.02, p = 0.028) and worse performance on: Trail Making Test A (β= 0.05, p < 0.001) and B (β= 0.057, p < 0.001), and Digit Symbol (β= -0.058, p < 0.001). Higher rFSRP scores were associated with increased odds for a greater volume of log-transformed WMH (OR = 1.02 per quartile, p = 0.015). No associations were observed for diagnosis, episodic memory or language test scores, HCV, or TBV. Conclusion: These results support the rFSRP as a useful metric to facilitate clinical research on the associations between cerebrovascular disease and cognitive and brain aging.
Databáze:	MEDLINE
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