The Progression of SARS Coronavirus 2 (SARS-CoV2): Mutation in the Receptor Binding Domain of Spike Gene.

Autor:	Kim S; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.; College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea., Lee JH; Department of Laboratory Medicine, College of Medicine, Yeungnam University, Daegu 42415, Korea., Lee S; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.; YbdYbiotech Research Center, Seoul 08589, Korea., Shim S; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea., Nguyen TT; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.; College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea., Hwang J; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea., Kim H; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea., Choi YO; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea., Hong J; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.; College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea., Bae S; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.; Cardiovascvular and Neuropharmacological Drugs Division, Drug Evaluation Department, Ministry of Food and Drug Safety, Cheongju 28159, Korea., Jhun H; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.; Technical Assistance Center, Korea Food Research Institute, Wanju 55365, Korea., Yum H; Pulmonary Science and Critical Care Medicine, Seoul Paik Hospital, Inje University, Seoul 04551, Korea., Lee Y; Department of Medicine, Pusan Paik Hospital, Collage of Medicine, Inje University, Busan 47392, Korea., Chan ED; Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO 80206, USA., Yu L; Barbara Davis Center for Diabetes, University of Colorado Denver, Aurora, CO 80045, USA., Azam T; Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA., Kim YD; Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Yeungnam University, Daegu 42415, Korea., Yeom SC; Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang 25354, Korea., Yoo KH; Division of Pulmonology, Department of Internal Medicine, School of Medicine, Konkuk University, Seoul 05029, Korea., Kang LW; Department of Biological Sciences, Konkuk University, Seoul 05029, Korea., Shin KC; Center for Respiratory Disease, Yeungnam University, Daegu 42415, Korea., Kim S; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.; College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.; Veterinary Science Research Institute, Konkuk University, Seoul 05029, Korea.
Jazyk:	angličtina
Zdroj:	Immune network [Immune Netw] 2020 Oct 26; Vol. 20 (5), pp. e41. Date of Electronic Publication: 2020 Oct 26 (Print Publication: 2020).
DOI:	10.4110/in.2020.20.e41
Abstrakt:	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a positive-sense single-stranded RNA (+ssRNA) that causes coronavirus disease 2019 (COVID-19). The viral genome encodes twelve genes for viral replication and infection. The third open reading frame is the spike ( S ) gene that encodes for the spike glycoprotein interacting with specific cell surface receptor - angiotensin converting enzyme 2 (ACE2) - on the host cell membrane. Most recent studies identified a single point mutation in S gene. A single point mutation in S gene leading to an amino acid substitution at codon 614 from an aspartic acid 614 into glycine (D614G) resulted in greater infectivity compared to the wild type SARS-CoV2. We were interested in investigating the mutation region of S gene of SARS-CoV2 from Korean COVID-19 patients. New mutation sites were found in the critical receptor binding domain (RBD) of S gene, which is adjacent to the aforementioned D614G mutation residue. This specific sequence data demonstrated the active progression of SARS-CoV2 by mutations in the RBD of S gene. The sequence information of new mutations is critical to the development of recombinant SARS-CoV2 spike antigens, which may be required to improve and advance the strategy against a wide range of possible SARS-CoV2 mutations. Competing Interests: Conflict of Interest: The authors declare no potential conflicts of interest. (Copyright © 2020. The Korean Association of Immunologists.)
Databáze:	MEDLINE
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